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- John R. Abney Papers, 1887-1950
- Anonymous letter, 20 Mar. 1804 (Boston, Mass.), to "My dear Welles"
- Anonymous letter, 10 Mar. 1862 (Hilton Head, S.C.), to "Dear Mary" [Massachusetts]
- Anonymous shipping volume, 1874, [of Southern Express Company]
- Armstrong Family Papers, 1901-1926
- D. Joseph Atkinson volumes, 1853-1893
- Helen Barnwell Composition, May 1855, "Description of Beaufort [S.C.] in 1855"
- Five dollar note, 1816, issued by the Bridge Company of Augusta, [Ga.]
- Records, 1931-1947, of Cain's Mill Club (Sumter County, S.C.)
- Letter, 22 July 1841, J[ohn] C. Calhoun (Washington, D.C.) to C[harles] Yancey (Buckingham, Va.)
- [List of Subscribers, ca. 1880, of] the Charleston Telephonic Exchange
- Records of the Chester and Lenoir Narrow Gauge Rail Road, 1874-1899
- Letter, 29 Mar. 1821, Joseph Clarke (Charleston, S.C.) to Miss Louisa Bourne (Middleborough, Mass.)
- Letter, 15 Feb. 1945, W.J. Clawson [York, S.C.] to C.L. Clawson [Lancaster County, S.C.]
- Letter, 3 Apr. 1862, J[ohn] C. Clemson (Charleston, S.C.) to "Dear Uncle"
- Letter, 20 Mar. 1822, from Dr. Thomas Cooper
- Samuel Dibble Papers, 18 May [18]61 to 27 Feb. 1865 [Addition]
- Letter, 9 Oct. 1880, Samuel Dibble (Orangeburg, S.C.) to Pierre Odell (Akron, Ohio)
- Bill of sale, 21 Nov. 1789, for male slave, "Smithfield," sold by Howell Edmonds of Southampton County, Va.
- Evans Family Papers, 1826-1956
- Ford Family Papers, 21 May 1810 - 28 July 1907
- Frierson Family Papers, 1858-1932
- Samuel F. Garlington volumes, ca. 1881-1892, and undated photograph
- John Gibbs Papers, 1838-1876
- Letter, 1 Aug. 1837, R. Hackett (Pendleton, S.C.) to Patrick Calhoun (West Point, N.Y.)
- Letter, 2 Mar. 1931, Dorothy Heyward (Hendersonville, N.C.) to Mrs. E.C. Plimpton (Newton Center, Mass.)
- James Himrod Papers, 1861-1864
- Martha Caroline Ramsay Hopkins Papers, 1925-1940
- Letter, 29 Dec. 1822, John C. Hoyt (Pendleton, S.C.) to George Dickinson (Georgetown, S.C.)
- Records, 1925-1942, of the James Island Ginning Company
- Broadside, 7 Feb. 1859, from Kinsler's Hall (Columbia, S.C.) promoting "First Night of the New Orleans English Opera Company!"
- "List of Negroes," 4 Dec. 1855, at "Ladys Island" (Beaufort County, S.C.)
- Francis Lieber Papers, 1846-1872 [Addition]
- Matthias Washington Mabry Papers, 1842-1898
- John Charles McClenaghan Papers, 1853-1865
- Letter, 31 Dec. 1861, Chris C. McKinney (Camp Pocotaligo, S.C.) to Mary [McKinney] (Petersburg, Tenn.)
- South Carolina College diploma and Euphradian Society certificate, Dec. 1849,
of John B. Moore
- Receipt, 18 Apr. 1744, for "salary due" to George Morley, Provost Marshal of South Carolina
- Travel journal, 18 June 1865 - 21 Mar. 1866 of Miss M. F. Norris
- Papers, 1786-1857, of the Peronneau and Porcher Families
- Affidavit, 26 Oct. 1855, (Kershaw District, S.C.) regarding the Pettifoot Family
- Marriage bond, ca. May 1824 (St. John’s Parish, Berkeley District, S.C.), between the trustees of Mary Porcher
- Papers, 1861-1905, of the Quattlebaum and Atkinson Families
- Papers, 20 Oct. 1861 - 29 Aug. 1864, Reaves and McDowell Familes
- Journal, 1881-1933 and 1980-1990 (Marlboro County, S.C.), of Elizabeth "Bettie" Rebecca Thomas Sampson
- Letter, 2 Jan. 186[1], Rob[er]t A[nderson] Thompson (Charleston, S.C.) to Nean [Craig] (Pickens District, S.C.)
- Letter, 24 Oct. 1863, Hiram [Tweed] (Folly Island, S.C.) to "My Dear Libbie" (Delaware County, N.Y.)
- Hiram P. Tweed Papers, 1863-1865
- Webster's Academy of Penmanship and Stylographical Card Drawing, (Charleston, S.C.) 2 May 1842 [Broadside]
- Joanne Woodward playbills, 1946-1958 (Greenville, S.C.) [Addition]
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