
The new president of the University of South Carolina will be the institution's 28th since 1804, when Johnathan Maxcy became the first to lead South Carolina College, the University's precursor.
| Andrew A. Sorensen | 2002-2008 |
| John M. Palms | 1991-2002 |
| James B. Holderman | 1977-1990 |
| William H. Patterson | 1974-1977 |
| Thomas F. Jones | 1962-1974 |
| Robert L. Sumwalt | 1957-1962 |
| Donald S. Russell | 1952-1957 |
| Norman M. Smith | 1945-1952 |
| J. Rion McKissick | 1936-1944 |
| Leonard T. Baker | 1931-1936 |
| Davison M. Douglas | 1927-1931 |
| William D. Melton | 1922-1926 |
| William Spenser Currell | 1914-1922 |
| Samuel Chiles Mitchell | 1909-1913 |
| Benjamin Sloan | 1903-1909 |
| Franklin C Woodward | 1897-1902 |
| James Woodrow | 1891-1897 |
| John M. McBryde | 1882-1883 |
| William Porcher Miles | 1880-1882 |
| Augustus Baldwin Longstreet | 1857-1861 |
| Charles F. McCay | 1855-1857 |
| James Henley Thornwell | 1851-1855 |
| William Campbell Preston | 1845-1851 |
| Robert Henry | 1841-1845 |
| Robert W. Barnwell | 1835-1841 |
| Thomas Cooper | 1821-1834 |
| Jonathan Maxcy | 1804-1820 |
| Gaps in the presidential timeline indicate periods when the University was closed or under interim leadership or when its chief executive was known by a different title. | |
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