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  NIH: Development of Clinically Relevant In Vitro Performance Test for Generic OIDPs: Physiologically Relevant Models for Aerodynamic Particle Size Distribution Analysis (U01)RFA-FD-14-022

The goal of this project is to investigate if realistic physical mouth-throat (MT) models provide better predictability over pharmaceutical induction port assembly, for aerodynamic particle size distribution (APSD) characterization of orally inhaled drug products (OIDPs). Because there are different MT models proposed in the literature, in vivo predictability of several pre-screened MT models will be evaluated under different flow rate conditions, to select the optimal model(s). Upon successful completion, this research will provide a more realistic APSD characterization method that can be used as a pharmaceutical development tool in the early stages of OIDP development.

USC may only submit one application in response to this program announcement. Your application submission MUST be coordinated with the Office of the Vice President for Research. Please send a two page abstract via email to Richard White (whitejrw@mailbox.sc.edu) by May 1, 2014. In addition to the 2-page abstract, you should also submit a biosketch for the PI.

NIH indicates that a letter of intent is Not Applicable and a full proposal is due by June 1, 2014. For more information: http://grants.nih.gov/grants/guide/rfa-files/RFA-FD-14-022.html
   
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