Faculty and Staff
R. Michael Gower
|Title:||Assistant Professor, Chemical Engineering, Biomedical Engineering
|Department:||Chemical Engineering, Biomedical Engineering
College of Engineering and Computing
Swearingen Engineering Center
|Resources:||Curriculum Vitae [pdf]|
Experience and Education
Assistant Professor, Chemical Engineering, University of South Carolina, 2014-Present
Postdoctoral Associate, Northwestern University, 2011-2014
Postdoctoral Associate, University of California Davis, 2010-2011
PhD, Biomedical Engineering, University of California Davis, 2010
BS, Chemical Engineering, Colorado School of Mines, 2004
Our research focuses on understanding the immune system in order to develop bio-instructive materials that stimulate specific immune responses. We aim to control immune cell migration to synthetic microenvironments that are engineered to program and expand regulatory immune cells as a therapeutic tool for inflammatory disease. This research utilizes controlled release of proteins, peptides, and small molecules via a biomaterial to direct regulatory immune cell differentiation, as characterized by epigenetic modification to DNA, transcriptional programs, protein expression, and immunosuppressive function. We employ these technologies in animal disease models with the long-term goal of developing translational therapies for atherosclerosis, diabetes, and cancer.
Liu JM, Zhang J, Zhang X, Hlavaty KA, Ricci CF, Leonard JN, Shea LD, and Gower RM. Transforming growth factor-beta 1 delivery from microporous scaffolds decreases inflammation post-implant and enhances function of transplanted islets. Biomaterials Feb;80:11-9, 2016.
Gower RM, Boehler RM, Azarin SM, Ricci CF, Leonard JN, and Shea LD. Modulation of leukocyte infiltration and phenotype in microporous tissue engineering scaffolds via vector induced IL-10 expression. Biomaterials. 35(6):2024-31, 2014.
Boehler RM, Shin S, Fast AG, Gower RM, and Shea LD. A PLG/Hap composite scaffold for lentivirus delivery. Biomaterials. 34(21):5431-8, 2013.
Graham JG, Zhang X, Goodman A, Pothoven K, Houlihan J, Wang S, Gower RM, Luo X, and Shea LD. PLG Scaffold Delivered Antigen-Specific Regulatory T Cells Induce Systemic Tolerance in Autoimmune Diabetes. Tissue Eng Part A. 19(11-12):1465-75, 2013.
Foster GA, Gower RM, Stanhope KL, Havel PJ, Simon SI, Armstrong EA. On-chip Phenotypic Analysis of Inflammatory Monocytes in Atherogenesis and Myocardial Infarction. Proc Natl Acad Sci U S A. 110(34):13944-9, 2013.
Gower RM,Wu H, Foster GA, Ballantyne CM, Knowlton AA, and Simon SI. CD11c/CD18 expression is upregulated on blood monocytes during hypertriglyceridemia and enhances adhesion to Vascular Cell Adhesion Molecule-1. Arterioscler Thromb Vasc Biol. 31(1):160-6, 2011.
BMEN321 – Biomonitoring and Electrophysiology
BMEN589 – Immunoengineering
Honors and Awards
National IDeA Symposium of Biomedical Research Excellence Young Investigator Travel
NUPF Postdoc Presentation Award, 2013
IBIS Travel Award, 2012