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School of Medicine


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Cardiovascular Development and Disease

In 2011, the American Heart Association stated that by 2030 over 40 percent of the U.S. population would suffer from cardiovascular disease. We hit that mark in 2015. Now more than ever, our research is needed to improve the health of people in our country. 

General Research Interests

Research on cardiovascular diseases is primarily pursued by faculty members in the Department of Cell Biology and Anatomy. They are actively involved in research that focuses on:

  • Molecular, structural and hormonal basis of cardiac and vascular development
  • Injury and repair following stress
  • Remodeling and associated changes

 

Our Researchers

Researchers Research Focus Keywords
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Wayne E. Carver, Ph.D.

Extracellular matrix(fibroblast) behavior and gene expression in cardiovascular disease.

 

Taixing Cui, M.D., Ph.D.

Molecular and cellular mechanism that links obesity, diabetes and vascular disease, with a specific focus on the role of ubiquitin-proteasome system (Keap1-mediated Nrf2 ubiquitination and deubiquitinating enzymes, UCH-L1- or CYLD) in the maintenance of vascular homeostasis.

 

Daping Fan, M.D., Ph.D.

Role of macrophage Apolipoprotein E (ApoE), oxidized LDL (oxLDL), toll-like receptors (TLRs) and microRNA (miRNA155) in regression of atherosclerotic plaques

 

Edie Goldsmith, Ph.D.

Extracellular matrix, collagen, its receptor (DDR1 and DDR2) and gold nanoparticles in collagen remodeling and cardiac development.

 

Rich Goodwin, Ph.D.

Mechanisms of embryology, in vitro tissue regeneration, coronary vascular and cardiac regeneration.

 

Sue Lessner, Ph.D.

Mechanical properties of mouse atherosclerotic lesions and to develop mathematical models to describe their biomechanical behavior before and after drug treatment.

 

Mitzi Nagarkatti, Ph.D.

Immunotherapy for Cardiovascular disorders; vascular leak syndrome

 

Prakash Nagarkatti, Ph.D.

Role of immune cells in vasculitis

 

Chandrashekhar Patel, Ph.D.

Molecular regulation of vascular endothelial and smooth muscle cells.

 

Jay D. Potts, Ph.D.

Congenital cardiac malformations- Development of atrioventricular (AV) canal – AV valves and interventicular septum

 

Robert Price, Ph.D.

Molecular and cell biology instrumentation for in vitro, in vivo and whole body imaging studies of embryonic, fetal, neonatal and adult animals. Primary interests involve the roles of growth factors and mechanical forces on the development and function of myofibrils in cardiac myocytes.

 

Ann Ramsdell, Ph.D.

Etiology of congenital heart defects — emphasis on role of cardiac laterality genes in overall heart morphogenesis.

 

Ali Rizvi, M.D.

Diabetes and Cardiovascular disease

 

Patricia Witherspoon, M.D.

Community Health Care Advocacy and Cardiovascular Diseases