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College of Arts and Sciences

Faculty and Staff

Hexin Chen

Title: Associate Professor
Department: Biological Sciences
College of Arts and Sciences
Phone: 803-777-2928
Office: PSC, Room 621
Resources: Department of Biological Sciences


Kanojia D, Zhou W, Zhang J, Jie C, Lo PK, Wang Q and Chen H. 2012. Proteomic profiling of cancer stem cells derived from primary tumors of HER2/Neu transgenic mice. Proteomics. (in press).

Lo, PK and Chen H. 2012. Cancer stem cells and cells-of-origin in MMTV-Her2/neu induced mammary tumorigenesis. Oncogene. (in press). .

Duan X, Li H, Chen H and Q Wang. 2012. Discrimination of colon cancer stem cells using noncanonical amino acid. Chem. Commun.. 48, 9035–9037.

Sharmistha S, P.K. Lo, X Duan, Chen H*, and Wang*. 2012. Extracellular-matrix proteins regulate fate of tumor initiating cells in breast cancer. Integrative Biol.4, 897-904. (*corresponding author and top ten most accessed articles in June 2012). .

Wang S, D. Kanojia, P.K. Lo, V. Chandrashekaran, X. Duan, F.G. Berger, Q. Wang and H. Chen. 2012. Tumorspheres derived from colorectal cancer cell lines are enriched in cancer stem cells that can be preferentially eliminated by a DNA methylation inhibitor. Human Genetics and Embryology . S02-006.

Saha, S, X. Duan, L. Wu, P.K. Lo, H. Chen*, and Q. Wang*. 2012. Electrospun Fibrous Scaffolds Promote Breast Cancer Cell Alignment and Epithelial-Mesenchymal Transition. Langmuir. 28(4):2028-34. (*corresponding author). .

Lo, P. K., D. Kanojia, X. Liu, U. P. Singh, F. G. Berger, Q. Wang and H. Chen. 2012. CD49f and CD61 identify Her2/neu-Induced mammary tumor Initiating cells that are potentially derived from luminal progenitors and maintained by the integrin-TGFβ signaling. Oncogene. 31(21):2614-26. .

Kanojia D and Chen H. 2011. The microenvironment and breast cancer stem cells. Breast Cancer Cells / Book 4, ISBN 978-953-307-1332-4. Intech Publisher. p237-246.

Jo H, Lo PK, Li Y, Loison F, Green S, Wang J, Silberstein LE, Ye K, Chen H*, and Luo H*. 2011. Deactivation of Akt by a small molecule inhibitor targeting pleckstrin homology domain and facilitating Akt ubiquitination. Proc Natl Acad Sci USA. 108:6486-91. (highlighted in Nature Chem. Biol. 2011, 7:340). (*corresponding author)

Yu F, Li J, Fu, J, Chen H, Ray S, Huang S and Ai W. 2011. Kruppel-like factor 4 (KLF4) is required for self-renewal of cancer stem cells and promotes migration and invasion of mammary cancer cells. Oncogene. 30:2161-72.

Gu Y, Fu J, Lo P, Wang Q and Chen H. 2011. The effect of B27 supplement on promoting in vitro propagation of Her2/neu-transformed mammary tumorspheres. J. Biotech Res. 3:7-18.

Zhang X, Wan G, Mlotshwa S, Vance V, Berger FG, Chen H and Lu X. 2010. Oncogenic Wip1 Phosphatase is Inhibited by miR-16 in the DNA Damage Signaling Pathway. Cancer Res. 70:7176-86.

Chen H*, Pimienta G, Gu Y, Kim M-S, Chaerkady R, Gucek M, Cole RN, Sukumar S and Pandey A*. 2010. Proteomic phenotype of HER2-expressing mammary epithelial cells using SILAC. Proteomics. 10:3800-10.

Chen H, Lee JS, Liang X, Zhang H, Zhu T, Zhang Z, Taylor ME, Zahnow C, Feigenbaum L, Rein A and Sukumar S. 2008. Hoxb7 inhibits transgenic HER2/neu-induced mouse mammary tumor onset but promotes progression and lung metastasis. Cancer Res. 68:3637-44.