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College of Engineering and Computing


Biomedical Engineering

The Role of Myeloid Cell MicroRNA-155 in Atherosclerosis and Cancer

miR155 is one of the first identified microRNAs with multiple functions. miR155-/- mouse model was the first mouse model with a microRNA deficiency. miR155 plays a crucial role in immune cell development and function, and is a positive feedback molecular in TLR-mediated macrophage inflammatory responses. miR155 has been considered as a oncogene in multiple blood cancers and several solid tumors. In this project, we use a wide range of molecular and cell biology approaches, as well as genetically modified animal models to investigate: 1) The role of miR155 in macrophage inflammatory responses, lipid homeostasis and apoptosis in the context of atherogenesis; 2) The role of miR155 in myeloid cell (macrophage, myeloid-derived suppressor cell, and dendritic cell) differentiation and function in breast cancer.

Publications

• Fang Yu, Xuemei Jia, Fen Du, Junfeng Wang, Yuzhen Wang, Walden Ai, and Daping Fan. miR-155-Deficient Bone Marrow Promotes Tumor Metastasis. (2013) Molecular Cancer Research, 2013 Aug;11(8):923-36. doi: 10.1158/1541-7786.MCR-12-0686. Epub 2013 May 10. PMID: 23666369

• Fen Du; Fang Yu; Yuzhen Wang; Yvonne Hui; Kevin Carnevale; Mingui Fu; Hong Lu; Daping Fan. microRNA-155 deficiency results in decreased macrophage inflammation and attenuated atherogenesis in apoE-/- mice. Arterioscler Thromb Vasc Biol. 2014 Apr; 34(4):759-769. PMID: 24504735 PMCID: PMC4036084

• Junfeng Wang, Fang Yu, Xuemei Jia, Stephen Iwanowycz, Yuzhen Wang, Shiang Huang, Walden Ai and Daping Fan. MicroRNA-155 deficiency enhances the recruitment and functions of myeloid-derived suppressor cells in tumor microenvironment and promotes solid tumor growth. (2015) International Journal of Cancer, 2015 Mar 15;136(6):E602-13. PMID: 25143000