It has been proposed that soft tissues evolve in concert with their local environment to achieve optimal mechanical operation. In vascular tissue, this adaptation results in a uniform circumferential stress distribution throughout the vascular wall, which in turn ensures that resident mechanosensitive vascular cells are sensing and responding equivalent mechanical stimuli. The resultant coordination of vascular cell behavior ensures that the vessel can realize its intended functions as a conduit for blood flow and a modulator of blood flow pulsatility in a metabolically efficient manner. Though a series of integrated theoretical and experimental studies, we confirm the existence of this optimal mechanical operation is various tissue beds and scenarios, including the aortic arch, descending aorta, and local to endovascular implants, and seek relate findings to the genesis and progression of certain disease states as well as the advancement of tissue engineering and endovascular technologies.
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