Faculty and Staff
Abdol-Hossein Rezaeian, Ph.D.
|Title:||Research Assistant Professor
|Department:||Drug Discovery & Biomedical Sciences (DDBS)
College of Pharmacy
College of Pharmacy
715 Sumter Street - CLS 618
Columbia, SC 29208
Ph.D. Molecular Genetics/Biotechnology, Tokyo University A&T, 2009
Rezaeian completed his Ph.D. with a focus on the pathobiology of the CT/CGRP gene family and related Natural Antisense Transcripts in the brain development at Tokyo University A&T in 2009. He completed postdoctoral training on Molecular and Cellular Oncology at MD Anderson Cancer Center and was then promoted to Instructor at Department of Molecular Cellular Oncology from 2009 to 2016.
Rezaeian joined Houston Methodist Research Institute as a Senior Research Associate in 2017 and was awarded an instructor position. He has studied microenvironmental regulation of tumor progression and impact of activating hypoxia signaling pathways during metastatic breast cancer to the brain with related implications for cancer therapeutics.
Rezaeian discovered a novel TRAF6/H2AX/HIF1a signaling pathway which promotes breast tumor metastasis and resistance to DNA damaging therapeutics. He has also developed strategies to simultaneously target both angiogenesis and chemo-resistance in several solid and lymphoid tissue tumor models.
Through outlining various targets regulated by hypoxia, Rezaeian investigates other unique factors and drug targets for deregulation of cancer cell properties such as energy metabolism, metabolic reprogramming, angiogenesis, stemness, growth and differentiation within the complex cross talk in neuro-immune systems. This investigation is also an awakening field because of growing focus on tissue integrity and cancer cell dormancy in triple negative breast cancer with no reliably effective therapeutic options.
Rezaeian AH*, Khanbabaei H, Calin GA*. Therapeutic Potential of the microRNA-ATM Axis in the Management of Tumour Radioresistance. Cancer Res. 2020 Jan 15; 89 (2): 139-150. *Correspondence authors
Jin G, Xu C, Zhang X, Long J, Rezaeian AH, Liu C, Furth ME, Kridel S, Pasche B, Bian XW, Lin HK. Atad3a suppresses Pink1-dependent mitophagy to maintain hematopoietic progenitor homeostasis. Nature Immunol. 2018 Jan 19 (1): 29-40.
Zhang X, Li B, Rezaeian AH, Xu X, Chou PC, Jin G, Han F, Pan BS, Wang CY, Long J, Zhang A, Huang CY, Tsai FJ, Tsai CH, Logothetis C, Lin HK. H3 ubiquitination by NEDD4 regulates H3 acetylation and tumorigenesis. Nature Comm. 2017 Mar 16; 8:14799.
Rezaeian AH, Wang YH, Lin HK. DNA damage players are linked to HIF-1a/hypoxia signaling. Cell Cycle. 2017 Apr 18; 16 (8): 725-726.
Rezaeian AH*, Li CF, Wu CY, Zhang X, Delacerda J, You MJ, Han F, Cai Z, Jeong YS, Jin G, Phan L, Chou PC, Lee MH, Hung MC, Sarbassov D, Lin HK*. Hypoxia-responsive TRAF6-ATM-H2A.X signalling axis promotes HIF1α activation, tumorigenesis and metastasis. Nature Cell Biol. 2017 Jan; 19 (1): 38-51. *Correspondence authors
Zhang X, Li CF, Zhang L, Wu CY, Han L, Jin G, Rezaeian AH, Han F, Liu C, Xu C, Xu X, Huang CY, Tsai FJ, Tsai CH, Watabe K, Lin HK. TRAF6 Restricts p53 Mitochondrial Translocation, Apoptosis, and Tumor Suppression. Mol Cell. 2016 Nov 17; 64 (4): 803-814.
Jin G, Lee SW, Zhang X, Cai Z, Gao Y, Chou PC, Rezaeian AH, Han F, Wang CY, Yao JC, Gong Z, Chan CH, Huang CY, Tsai FJ, Tsai CH, Tu SH, Wu CH, Sarbassov dos D, Ho YS, Lin HK. Skp2-Mediated RagA Ubiquitination Elicits a Negative Feedback to Prevent Amino-Acid-Dependent mTORC1 Hyperactivation by Recruiting GATOR1. Mol Cell. 2015 Jun 18; 58(6):989-1000.
Xu D, Li CF, Zhang X, Gong Z, Chan CH, Lee SW, Jin G, Rezaeian AH, Han F, Wang J, Yang WL, Feng ZZ, Chen W, Wu CY, Wang YJ, Chow LP, Zhu XF, Zeng YX, Lin HK. Skp2-MacroH2A1-CDK8 axis orchestrates G2/M transition and tumorigenesis. Nature Comm. 2015 Mar 30; 6:6641.
Lee SW, Li CF, Jin G, Cai Z, Han F, Chan CH, Yang WL, Li BK, Rezaeian AH, Li HY, Huang HY, Lin HK. Skp2-Dependent Ubiquitination and Activation of LKB1 Is Essential for Cancer Cell Survival under Energy Stress. Mol Cell. 2015 Mar 19; 57 (6): 1022-33.
Rezaeian AH, Gao Y, Lin HK. Cloning, Expression, and Functional Analysis of Genomic miRNA Using Retroviral System in Cancer Cells. Methods Mol Biol. 2013; 936:157-72.
Chen D, Sun Y, Wei Y, Zhang P, Rezaeian AH, Teruya-Feldstein J, Gupta S, Liang H, Lin HK, Hung MC, Ma L. LIFR is a breast cancer metastasis suppressor upstream of the Hippo-YAP pathway and a prognostic marker. Nature Medicine. 2012 Sep 23; 18(10):1511-7. PMID: 23001183.
Wu J, Zhang X, Zhang L, Wu CY, Rezaeian AH, Chan CH, Li JM, Wang J, Gao Y, Han F, Jeong YS, Yuan X, Khanna KK, Jin J, Zeng YX, Lin HK. Skp2 E3 ligase integrates ATM activation and homologous recombination repair by ubiquitinating NBS1. Mol Cell. 2012 May 11; 46(3):351-61. PMID: 22464731.
Tao RH, Berkova Z, Wise JF, Rezaeian AH, Daniluk U, Ao X, Hawke DH, Karp JE, Lin HK, Molldrem JJ, Samaniego F. PMLRAR binds to Fas and suppresses Fas-mediated apoptosis through recruiting c-FLIP in vivo. Blood. 2011 Jul 29. [PMID: 21803845]
Rezaeian A.H., Isokane T., Nishibori M., Chiba M., Hiraiwa N., Yoshizawa M., Yasue H. “CGRPα and CGRPβ Transcript Amount in Mouse Tissues of Various Developmental Stages and Their Tissue Expression Sites”. Brain Development. 2009 Oct; 31(9): 682-93. PMID: 19062206
Rezaeian A.H., Katafuchi, T., Yoshizawa M., Hiraiwa, N., Saito, T., Nishibori M., Hamano, K., Minamino, N., Yasue H. “Genomic Organization, Expression and Evolution of Porcine CRSP1, 2, and 3”. Cytogenet. Genome Res. 2008; 121(1):41-9. PMID: 18544925