Prisma Health ASST (PHASST) published Impact of Penicillin Allergy on Empirical Carbapenem
Use in Gram-Negative Bloodstream Infections: An Antimicrobial Stewardship Opportunity.
Retrospective matched cohort study evaluating association between penicillin allergy
and empirical carbapenem use in gram-negative bloodstream infections (BSI) and utility
of antimicrobial stewardship interventions in reducing carbapenem utilization.
Julie Ann Justo leads PHASST publication on: Combination versus monotherapy for gram-negative
bloodstream infections: matching by predicted prognosis.
The utility of empirical combination antimicrobial therapy for gram-negative bloodstream
infections (BSI) remains unclear. This retrospective, quasi-experimental matched cohort
study examined the impact of empirical combination therapy on mortality in patients
with gram-negative BSI. Hospitalized adults with gram-negative BSI from 1 January
2010 to 31 December 2013 at Prisma Health Hospitals in Columbia, SC, USA were identified.
Brandon Bookstaver and colleagues publish Systematic review of antimicrobial lock
therapy for prevention of central-line-associated bloodstream infections in adult
and pediatric cancer patients.
Central venous catheter (CVC) use is commonplace in cancer patients. Antimicrobial
lock therapy (ALT), the instillation of a concentrated antimicrobial solution into
the catheter lumen, is one method for preventing infection among CVCs. This systematic
review discusses the effectiveness and safety of prophylactic ALT in cancer patients