Pharmacology has two major subdivisions:
- pharmacokinetics, which is concerned with the fate of drugs administered to a living organism
- pharmacodynamics, which is concerned with the physiological and biochemical study of drug effects
Research in pharmacology at the College of Pharmacy focuses on identifying new pharmacological targets for drugs, including various receptors and ion channels. A particular area of interest is developing new therapeutics for urinary bladder dysfunction. Overactive bladder (OAB) is a debilitating pathological condition affecting more than 34 million Americans at an annual cost of more than $65 billion in the United States alone. Current pharmacological therapies for OAB are limited in efficacy and relief.
Faculty members in the Department of Drugs Discovery and Biomedical Sciences employ a wide variety of techniques ranging from subcellular to the whole organism level to identify novel pharmacological targets, e.g. ion channels, for urinary bladder dysfunction. This includes state-of-the-art methodologies, such as patch-clamp electrophysiology, confocal microscopy, calcium imaging, isometric urinary bladder smooth muscle tension recording and various cellular and molecular approaches.