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Office of Research and Grant Development

Program Details

A Consortium for Gut-Brain Communication in Parkinson’s Disease (U01 Clinical Trial Not Allowed) RFA-DK-22-036 - Research Centers

Sponsor: NIH
Internal Deadline: 09/20/2023
Institutional Submission Limit: 1
Sponsor Deadline: 11/15/2023
Program Website

This Notice of Funding Opportunity (NOFO) invites new applications to participate in the Gut-Brain Communication in Parkinson’s Disease (PD) Consortium (GBPDC). The GBPDC will consist of up to six Gastroenterology Neurology Research Centers (GNRC) and one Coordinating and Data Management Center (CDMC).  The CDMC is fully described in the companion NOFO, RFA-DK-23-001.  The GNRC will serve as sites for enrollment of PD patients with and without GI symptoms as well as those with identifiable risk factors for PD, and healthy age-matched controls.  Biological samples obtained from these participants will be used for laboratory-based studies. The overall objectives of this consortium are 1) to accelerate research on the role of gastrointestinal (GI) symptoms and changes in gut-brain communication in the initiation and pathogenesis of Parkinson’s disease; and 2) to facilitate development and validation of innovative early-phase gut-brain based diagnostic tools and biomarkers for PD.  The activities of the GBPDC will include, but are not limited to,:1) harmonize participant recruitment and use of standardized protocols to collect data and biospecimens relevant to both neurology and gastroenterology research; 2) share data, biosamples, models, reagents, resources, and methods among projects in the GBPDC; and 3) make these publicly available through the CDMC.  NIDDK encourages applications from institutions that foster a diverse research environment,  (for more information, see, e.g., NOT-OD-20-031) , and encourage  Research on Sex/Gender Differences, Sexual and Gender Minority-Related Research and Race/Ethnic Diversity (see NOT-DK-22-003).

Submission Process

Limited submissions MUST be coordinated with the Office of the Vice President for Research.

If interested in applying for this opportunity, email a two-page project abstract, include at top the project title, PI, and list of key collaborators and a 2-3 page CV/biosketch for the PI (SCiENcv preferred) by the INTERNAL DEADLINE above to Julie Morris at

Office of Research and Grant Development

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