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Center for Clinical and Translational Research

Train Your Brain SC: An Exercise Intervention for People with Cognitive Impairments

Investigator Highlight

Elizabeth Regan, DPT, PhD

headshot Elizabeth Regan

Dr. Elizabeth Regan is a Clinical Associate Professor at the University of South Carolina, Floyd School of Medicine, USC Brain Health Network. She is a clinician-scientist focused on improving physical activity and community-based exercise programs for individuals with neurologic and mobility-related conditions. Her work integrates clinical care, behavioral interventions, and community partnerships to enhance health outcomes for individuals with chronic conditions, including stroke and cognitive impairment. She leads innovative research to increase access to effective, evidence-based exercise programs across South Carolina.

Research Team

Co-Investigator: Dr. Christine Pellegrini, Exercise Science, Arnold School of Public Health, University of South Carolina
Clinical Collaborator: James McMahon, Assistant Clinical Faculty, Nurse Practitioner, USC Brain Health Center

About the Project

This project aims to develop and evaluate a structured exercise and coaching program for individuals with mild to moderate cognitive impairments in South Carolina. Participants will engage in individualized, progressive exercise programs delivered either in-person or remotely, improving accessibility for both urban and rural populations. The program combines physical therapist supervision, real-time coaching, and technology-based monitoring to support adherence and track outcomes. Researchers will assess feasibility, participant engagement, and changes in cognitive and physical function over time. By expanding access to structured exercise interventions, this study addresses a critical gap in care for individuals experiencing cognitive decline.

AI-generated illustration of the Train Your Brain project- problem, intervention, outcomes

Why This Research Matters

Cognitive decline is a growing public health challenge that affects independence and quality of life. This project aims to provide scalable, community-based solutions that can slow decline, improve function, and reduce healthcare burden across South Carolina.

Interested in Learning More?

For additional information about this study or to get involved, please contact: Dr. Regan @ Eregan@uscmed.sc.edu or call 803-545-6556

 

Center for Clinical and Translational Research


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