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Office of Research and Grant Development

Program Details

NIH: NHGRI Genome Sequencing Program Analysis Centers (U01)RFA-HG-15-026

NHGRI seeks to establish NHGRI Genome Sequencing Program Analysis Centers (GSPAC), which will undertake computational analyses of the data produced by the NHGRI Genome Sequencing Program (GSP) with the purpose of extracting genomic and biological knowledge.

Specifically, the GSPACs will have two roles. First, they will undertake novel, investigator-initiated analyses that will cut across the individual projects and grants that are the primary data producing constituents of the overall GSP. These analyses may also use data generated by other large-scale genomics projects. GSPACs will develop improved or novel analyses and methods for all non-automated aspects of characterizing sequence variants in the data, after lower level data processing and variant calling. NHGRI has particular interest in questions about identifying associations between variants and disease phenotypes; analyses using existing functional data to leverage associations and/or make functional inferences; means to improve study design; and other higher level analyses.

Second, the GSPACs will work together with the other GSP components on cross-program analyses that are directly relevant to goals defined in the Companion Funding Opportunities, which currently include defining the point at which a common disease/rare variant genome sequencing study is comprehensive or complete, and developing specifications for sample sets that could serve as common controls for common disease genome sequencing studies.

USC may only submit only one application in response to this program announcement. Your application submission MUST be coordinated with the Office of the Vice President for Research. Please send a two page abstract via email to Richard White ( by June 18, 2015. In addition to the 2-page abstract, you should also submit a biosketch for the PI.

NIH indicates that a letter of intent is due July 25, 2015 and a full proposal is due by August 26, 2015. For more inforation:

Office of Research and Grant Development

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