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Department of Biological Sciences

Faculty and Staff Directory

Michael Felder

Title: Professor Emeritus
Department: Biological Sciences
College of Arts and Sciences
Phone: 803-777-5135
Office: GSRC, Room 311


Felder, M. R. 1978.  Mouse liver cytoplasmic malate dehydrogenase:  rapid isolation, characterization and immunological comparison with hepatoma enzyme.  Arch.   Biochem. Biophys. 190, 647-656.

Burnett, K. and M. R. Felder 1978. Genetic regulation of liver alcohol dehydrogenase in Peromyscus.  Biochem. Genet. 16, 443-454.

Burnett, K. and M. R. Felder.  1978.  Peromyscus alcohol dehydrogenase:  Lack of crossreacting material in enzyme negative animals.  Biochem. Genet. 16, 1093-1105. 

Burnett, K. and M. R. Felder. 1980. Ethanol metabolism in Peromyscus genetically deficient in alcohol dehydrogenase.  Biochem. Pharmacol. 28, 125-130.

Felder, M. R. 1980. Biochemical and developmental genetics of isozymes in the mouse, Mus musculus.  In Isozymes: Current Topics in Biological and Medical Research (eds. M. C. Rattazzi, J. G. Scandalios, G. S. Whitt) Alan R. Liss, Inc. N. Y. 4: 1-68.

Felder, M. R. and K. G. Burnett. 1982.  Some observations on ethanol metabolism in alcohol dehydrogenase negative deermice.  In Biological Approach to Alcoholism (ed. C. S. Lieber). NIAAA. Rockville, MD. Pp. 268-278.

Lebsack, M. E., M. R. Felder and C. S. Lieber.  1982. Hepatic aldehyde dehydrogenase activity   in Peromyscus genetically deficient in alcohol dehydrogenase.  Comp. Biochem.    Physiol. 72B, 517-519.

Balak, K., R. Keith and M. R. Felder. 1982. Genetic and developmental regulation of mouse liver alcohol dehydrogenase.  J. Biol. Chem. 257, 15000-15007.

Dawson, W. D., L. L. Huang, M. R. Felder and J. B. Shaffer. 1983.  Linkage relationships among eleven biochemical loci in Peromyscus.  Biochem. Genet. 21, 1101-1113.

Shigeta, Y., S. Nomura, S. Iida, M. A. Leo, M. R. Felder and C. S. Lieber. 1984.  Ethanol metabolism in vivo by the microsomal ethanol-oxidizing system in deermice lacking alcohol dehydrogenase (ADH).  Biochem. Pharmacol. 33, 807-814.

Glassman, E., G. McLaughlin, D. Forman, M. Felder and R. Thurman. 1985. Role of alcohol dehydrogenase in the swift increase in alcohol metabolism (SIAM). Studies with deermice deficient in alcohol dehydrogenase.  Biochem. Pharmacol. 34, 3523-3526.

Belinsky, S., B. Bradford, D. Forman, E. Glassman, M. Felder and R. Thurman. 1985. Hepatotoxicity due to allyl alcohol in deermice depends on alcohol dehydrogenase. Hepatology 5, 1179-1182.

Watson, G., M. R. Felder, L. Rabinow, K. Moore, C. Labarca, C. Tietze, G. Vander Moolen, L.   Bracey, M. Brabant, J. Cai and K. Paigen. 1985.  Properties of rat and mouse β-glucuronidase mRNA and cDNA, including evidence for sequence polymorphism and genetic regulation of mRNA levels.  Gene 36, 15-25.

Ceci, J., R. Lawther, G. Duester, G. W. Hatfield, M. Smith, M. O’Malley, and M. R. Felder. 1986. Androgen induction of alcohol dehydrogenase in mouse kidney.  Studies with a cDNA probe confirmed by nucleotide sequence analysis.  Gene 41, 217-224.

Ceci, J. D., Y.-W. Zheng, and M. R. Felder. 1987.  Molecular analysis of mouse alcohol dehydrogenase:  nucleotide sequence of the Adh1 gene and genetic mapping of a related nucleotide sequence to chromosome 3.  Gene 59, 171-182.

Felder, M. R., G. Watson, M. O’Malley and J. Ceci. 1988.  Mechanism of induction of mouse kidney alcohol dehydrogenase by androgen.  Androgen-induced stimulation of transcription of the Adh1 gene.  J. Biol. Chem. 263, 14531-14537.

Tussey, L. and M. R. Felder. 1989.  Tissue-specific genetic variation in the level of mouse alcohol dehydrogenase is controlled transcriptionally in kidney and posttranscriptionally in liver.  Proc. Natl. Acad. Sci. 86, 5903-5907.

Davis, J. F. and M. R. Felder. 1993.  Mouse ethanol-inducible cytochrome P450 (P450IIE1). Characterization of cDNA clones and testosterone induction in kidney tissue.  J. Biol.  Chem. 268, 16584-16589.

Zheng, Y.-W., M. Bey, H. Liu and M. R. Felder. 1993.  Molecular basis of the alcohol dehydrogenase negative deermouse:  Evidence for deletion of the gene for class I enzyme and identification of a possible new enzyme.  J. Biol. Chem. 268, 24933-24939.

Xie, D., P. Narasimhan, Y.-W. Zheng, M. J. Dewey and M. R. Felder. 1996.  Ten kilobases of 5’-flanking region confers proper regulation of the mouse alcohol dehydrogenase-1 (Adh1) gene in kidney and adrenal of transgenic mice.  Gene 181, 173-178.

Zheng, Y.-W. and M. R. Felder. 1997.  Genetic mapping of a possible new alcohol dehydrogenase exon 6 sequence to mouse chromosome 3 at the Adh1/Adh3 complex. Biochem. Genet. 35, 105-117.

Duester, G., J. Farres, M. R. Felder, R. S. Holmes, J-O. Hoog, X. Pares, B. V. Plapp, S-J. Yin, and H. Jornvall. 1999. Recommended nomenclature for the vertebrate alcohol dehydrogenase gene family. Biochem. Pharmacol. 58, 389-395

Jeong, K.-S., Y. Soh, J. Jeng, M. R. Felder, J. P. Hardwick, and B. J. Song. 2000.  Cytochrome P450 2E1 (CYP2E1)-dependent production of a 37-kD acetaldehyde-protein adduct in the rat liver. Arch. Biochem. Biophys. 384, 81-87

Dolney, D. E., G. Szalai, G. Duester, and M. R. Felder. 2001. Molecular analysis of genetic differences among inbred mouse strains controlling tissue expression pattern of alcohol dehydrogenase 4.  Gene 267, 145-156

Dolney, D. E. A., G. Szalai, and M. R. Felder.  2001. Differences in charge and kinetic properties of alcohol dehydrogenase 4 from C57BL/6 mice compared to other inbred strains are associated with a cysteine120 to arginine120 substitution. Biochem. Genet. 39, 239-250

Szalai, G., G. Duester, R. Friedman, H. Jia, S-P. Lin, B. A. Roe and M. R. Felder. 2002. Organization of six functional mouse alcohol dehydrogenase genes on two overlapping bacterial artificial chromosomes.  Eur. J. Biochem. 269, 224-232

Szalai, G., D. Xie, M. Wassenich, M. Veres, J. D. Ceci, M. J. Dewey, A. Molotkov, G. Duester,   and M. R. Felder. 2002.  Distal and proximal cis-linked sequences are needed for the total expression phenotype of the mouse alcohol dehydrogenase 1 (Adh1) gene.  Gene 292, 259-270.

Westerland, M., A. C. Belin, M. R. Felder, L. Olson, and D. Galter. 2007.  High and  complementary expression patterns of alcohol and aldehyde dehydrogenases in the gastrointestinal tract: implications for Parkinson’s disease.  FEBS J. 274, 1212-1223.

Szalai, G., M. Veres, G. Duester, R. Lawther, M. Lockhart,  G. Duester and M. R. Felder.  Tissue expression pattern of class II and class V genes found in the Adh-complex on mouse chromosome 3.  Biochem. Genet. 46, 685-695.

Anvret, A., Ran, C., Westerlund, M., Gellhaar, S., Lindqvist, E., Pernold, K., Lundstromer, K.,    Duester, G., Felder, M. R., Galter, D., and Belin, A. C. 2011.  Adh1 and Adh1/4 knockout mice as possible rodent models for presymptomatic Parkinson’s disease.  Behav. Brain. Res. 227, 252-257.

Shorter, K. R., Crossland, J. P., Webb, D., Szalai, G., Felder, M. R., and Vrana, P. B. 2012.  Peromyscus as a mammalian epigenetic model.  Genetics Res. International.  Vol. 2012, ID179159,11 pages

Kenney-Hunt, J., Lewandowski, A., Glenn, T.C., Glenn,  Glenn, J. L., Tsyusko, O. V., O’Neill,   R.J., Ramsdell, C. M., Nguyen, Q., Phan, R., Shorter, K. S., Dewey, M. J., Szalai, G., Vrana, P. B., and Felder, M. R. 2014. A genetic map of  Peromyscus with chromosomal assignment of linkage groups. Mammal. Genome 25:160-179.  (COVER PICTURE)

Vrana, P. B., Shorter, K. R., Szalai, G., Felder, M. R., Crossland, J. P., Veres, M., Dewey, M. J., and Dawson, W. D. 2013. Wiley Interdisciplinary Reviews: Developmental Biology Doi:10.1002/wdev.132.

Shorter, K. R., Owen, A., Anderson, V., Hall-South, A. C., Hayford, S., Cakora, P., Crossland, J. P., Georgi, V. R. M., Perkins, A., Kelly, S. J., Felder, M. R., and Vrana, P. B. 2014.    Natural genetic variation underlying differences in Peromyscus repetitive and social/aggressive behaviors.  Behav. Genet. 44: 126-135.

Weidmeyer, C. C., Crossland, J. P., Dewey, M. J. Felder, M. R., Barlow, S. C., Vrana, P. B., and  Szalai, G. 2014.  Comparative hematological and serum biochemical values among Peromyscus species and their hybrids.  J. Amer. Assoc. Lab Animal Science.  53:336-343.

Shorter, K., Anderson, V., Cakora, P., Owen, A., Dave, K., Crossland, J. P., South, A. C. H., Felder, M. R. and Vrana, P. B. 2014  Pleiotropic effects of a methyl-donor diet on a novel animal model. PLOS ONE .  9: Issue 8, e104942

Crossland, J. P., Dewey, M. J., Barlow, S. C., Vrana, P. B., Felder, M. R., and Szalai, G.  2014.  Caring for Peromyscus spp. in research environments.  Lab Animal  43(5): 162-166 (Cover Picture)

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