Research Concentration - Neurobiology
College of Arts and Sciences
|Resources:||Smith Lab Website|
We study pathways that regulate intracellular trafficking in neural cells. More specifically, we investigate how cytoplasmic dynein is regulated by LIS1 and related proteins in mammalian nervous systems. We are particularly interested in how these dynein regulators impact axonal transport, a process vital to the maintenance of neural circuits and to neural health. Currently, we are studying the effect of LIS1 missense mutations in cultured neurons and exploring how LIS1 depletion impacts nervous system function in mice. We are defining the role of LIS1 in both neurons and glial cells in the mouse nervous system.