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Department of Biological Sciences

Dr. Lydia Matesic coauthored an article in Science


The protein PTEN is a phosphatase and tumor suppressor whose activity is often decreased in human cancers. Thus, reactivating such a protein could potentially be an effective therapy against cancer. In their study entitled "Reactivation of PTEN tumor suppressor for cancer treatment through inhibition of a MYC-WWP1 inhibitory pathway" published in Science,  Lee et al. identified a ubiquitin E3 ligase  named WWP1 as a PTEN-interacting protein that modifies PTEN and inhibits its tumor suppressive activity. A natural compound found to be a pharmacological inhibitor of WWP1 inhibits tumor growth in a mouse model of prostate cancer. Thus, reactivation of the tumor suppressor PTEN may provide a strategy for battling tumors. Congrats to Lydia who contributed to this amazing study!

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