Localization and translation of mRNAs in subcellular regions is a critical mechanism by which polarized cells establish and maintain the specialized domains that are needed for their polarized functions. This is especially the case for neurons that have long cytoplasmic projections (dendrites and axons) that allow them to communicate with each other. In their recent review article entitled "The functional organization of axonal mRNA transport and translation", Jeff Twiss and his group discuss the regulation and function of RNA regulons, which are cohorts of functionally related mRNAs, in axon growth, guidance, injury responses, and survival. Learn more about this fascinating research here!
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- The Twiss lab published an article in Nature Reviews Neuroscience