Hutchinson-Gilford Progeria Syndrome (HGPS) is a rare, fatal autosomal dominant genetic condition characterized by accelerated aging in children. The mutation commonly associated with HGPS leads to the production of a truncated form of lamin A referred to as "progerin." Progerin is also expressed at very low levels in healthy individuals and appears to play a role in normal aging. HGPS is associated with an accumulation of genomic DNA double-strand breaks (DSBs), suggesting corruption of DNA repair. However, the role of progerin in DNA repair is not well known. In their recent study entitled "Alteration of genetic recombination and double-strand break repair in human cells by progerin expression", the Waldman lab investigated the influence of progerin expression on DSB repair in the human genome at the nucleotide level. Learn more about their discoveries here!
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- 2020 News Archive
- The Waldman lab published a new study in the journal DNA repair