Cancer therapies frequently fail because the patients’ tumors adapt to treatment and become both therapy resistant and more aggressive. Preventing this process could have a transformative impact on cancer treatment outcome. Drs. Hexin Chen, Professor in our Department, and Igor Roninson (College of Pharmacy) have been awarded a $402,707 grant from the National Cancer Institute to investigate whether inhibiting Mediator kinase proteins, which are involved in changing cellular gene expression, would prevent the development of therapy resistance and more aggressive properties in a major type of breast cancers. Congrats!