All Publications
A complete listing of all publications by Caryn Outten on PubMed, maintained by the National Center for Biotechnology Information. Some articles are free to download via PubMed Central (PMC).
Iron homeostasis proteins Grx4 and Fra2 control activity of the Schizosaccharomyces pombe iron repressor Fep1 by facilitating [2Fe-2S] cluster removal
Hati D, Brault A, Gupta M, Fletcher K, Jacques JF, Labbé S, Outten CE J Biol Chem. 2023 Dec;299(12):105419
The role of thiols in iron–sulfur cluster biogenesis
Bandyopadhyay T, Outten CE. In "Redox Chemistry and Biology of Thiols" B Alvarez, MA Comini, G Salinas, N Trujillo, Eds. Academic Press, 2022; p. 487-506.
Iron-sulfur cluster biogenesis, trafficking, and signaling: Roles for CGFS glutaredoxins and BolA proteins
Talib E, Outten CE Biochim Biophys Acta Mol Cell Res. 2021 Jan;1868(1):118847
Iron–sulfur cluster signaling: The common thread in fungal iron regulation
Gupta M, Outten CE Curr Opin Chem Biol. 2020 Apr;55:189-201
The conserved CDC motif in the yeast iron regulator Aft2 mediates iron-sulfur cluster exchange and protein-protein interactions with Grx3 and Bol2
Li H, Outten CE. J Biol Inorg Chem. 2019 Sep;24(6):809-815
Characterization of glutaredoxin Fe–S cluster-binding interactions using circular dichroism spectroscopy
Albetel AN, Outten CE. Methods Enzymol. 2018;599:327-53.
The role of Fe-S clusters in regulation of yeast iron homeostasis
Outten CE. In "Iron-Sulfur Clusters in Chemistry and Biology, 2nd Edition; Vol. 2: Biochemistry, Biosynthesis, and Human Diseases" T. Rouault, Ed. Walter de Guyter GmbH, Berlin/Boston, 2017; p. 161-186.
Checks and balances for the iron bank
Outten CE. J Biol Chem. 2017 Sep 22;292(38):15990-1.
Endoplasmic reticulum transport of glutathione by Sec61 is regulated by Ero1 and Bip
Ponsero AJ, Igbaria A, Darch MA, Miled S, Outten CE, Winther JR, Palais G, D'Autréaux B, Delaunay-Moisan A, Toledano MB. Mol Cell. 2017 Sep 21;67(6):962-73
Schizosaccharomyces pombe Grx4 regulates the transcriptional repressor Php4 via [2Fe–2S] cluster binding
Dlouhy AC, Beaudoin J, Labbé S, Outten CE. Metallomics. 2017 Aug 16;9(8):1096-1105
The E. coli BolA protein IbaG forms a histidine-ligated [2Fe-2S] bridged complex with Grx4
Dlouhy AC, Li H, Albetel AN, Zhang B, Mapolelo DT, Randeniya S, Holland AA, Johnson MK, Outten CE. Biochemistry. 2016 Dec 13;55(49):6869-79.
The myeloablative drug busulfan converts cysteine to dehydroalanine and lanthionine in redoxins
Scian M, Guttman M, Bouldin SD, Outten CE, Atkins WM. Biochemistry. 2016 Aug 23;55(33):4720-30.
Cytosolic Fe-S cluster protein maturation and iron regulation are independent of the mitochondrial Erv1/Mia40 import system
Ozer HK, Dlouhy AC, Thornton JD, Hu J, Liu Y, Barycki JJ, Balk J, Outten CE. J Biol Chem. 2015 Nov 13;290(46):27829-4.
The role of Fe-S clusters in regulation of yeast iron homeostasis
Outten CE. In "Iron-Sulfur Clusters in Chemistry and Biology," T. Rouault, Ed. Verlag Walter de Guyter GmbH, Berlin, Germany, 2014; p. 411-36.
Molecular mechanism and structure of the Saccharomyces cerevisiae iron regulator Aft2
Poor CB, Wegner SV, Li H, Dlouhy AC, Schuermann JP, Sanishvili R, Hinshaw JR, Riggs-Gelasco PJ, Outten CE, He C. Proc Natl Acad Sci U S A. 2014 Mar 18;111(11):4043-8.
Iron sensing and regulation in Saccharomyces cerevisiae: Ironing out the mechanistic details
Outten CE, Albetel AN. Curr Opin Microbiol. 2013 Dec;16(6):662-8.
The iron metallome in eukaryotic organisms
Dlouhy AC, Outten CE. Met Ions Life Sci. 2013;12:241-78.
Monothiol glutaredoxins and A-type proteins: partners in Fe-S cluster trafficking
Mapolelo DT, Zhang B, Randeniya S, Albetel AN, Li H, Couturier J, Outten CE, Rouhier N, Johnson MK. Dalton Trans. 2013 Mar 7;42(9):3107-15.
Functions and cellular compartmentation of the thioredoxin and glutathione pathways in yeast
Toledano MB, Delaunay-Moisan A, Outten CE, Igbaria A. Antioxid Redox Signal. 2013 May 1;18(13):1699-711.
Redox properties of the disulfide bond of human Cu,Zn superoxide dismutase and the effects of human glutaredoxin 1
Bouldin SD, Darch MA, Hart PJ, Outten CE. Biochem J. 2012 Aug 15;446(1):59-67.
Monothiol CGFS glutaredoxins and BolA-like proteins: [2Fe-2S] binding partners in iron homeostasis
Li H, Outten CE. Biochemistry. 2012 Jun 5;51(22):4377-89.
Redox-sensitive YFP sensors monitor dynamic nuclear and cytosolic glutathione redox changes
Dardalhon M, Kumar C, Iraqui I, Vernis L, Kienda G, Banach-Latapy A, He T, Chanet R, Faye G, Outten CE, Huang ME. Free Radic Biol Med. 2012 Jun 1-15;52(11-12):2254-65.
Human glutaredoxin 3 forms [2Fe-2S]-bridged complexes with human BolA2
Li H, Mapolelo DT, Randeniya S, Johnson MK, Outten CE. Biochemistry. 2012 Feb 28;51(8):1687-96.
Forging ahead: new mechanistic insights into iron biochemistry
Frey PA, Outten CE. Curr Opin Chem Biol. 2011 Apr;15(2):257-9.
Histidine 103 in Fra2 is an iron-sulfur cluster ligand in the [2Fe-2S] Fra2-Grx3 complex and is required for in vivo iron signaling in yeast
Li H, Mapolelo DT, Dingra NN, Keller G, Riggs-Gelasco PJ, Winge DR, Johnson MK, Outten CE. J Biol Chem. 2011 Jan 7;286(1):867-76.
The yeast iron regulatory proteins Grx3/4 and Fra2 form heterodimeric complexes containing a [2Fe-2S] cluster with cysteinyl and histidyl ligation
Li H, Mapolelo DT, Dingra NN, Naik SG, Lees NS, Hoffman BM, Riggs-Gelasco PJ, Huynh BH, Johnson MK, Outten CE. Biochemistry. 2009 Oct 13;48(40):9569-81.
Activation of Cu,Zn-superoxide dismutase in the absence of oxygen and the copper chaperone CCS
Leitch JM, Jensen LT, Bouldin SD, Outten CE, Hart PJ, Culotta VC. J Biol Chem. 2009 Aug 14;284(33):21863-71.
The redox environment in the mitochondrial intermembrane space is maintained separately from the cytosol and matrix
Hu J, Dong L, Outten CE. J Biol Chem. 2008 Oct 24;283(43):29126-34.
Structure of the thioredoxin-like domain of yeast glutaredoxin 3
Gibson LM, Dingra NN, Outten CE, Lebioda L. Acta Crystallogr D Biol Crystallogr. 2008 Sep;64(Pt 9):927-32.
Identification of FRA1 and FRA2 as genes involved in regulating the yeast iron regulon in response to decreased mitochondrial iron-sulfur cluster synthesis
Kumánovics A, Chen OS, Li L, Bagley D, Adkins EM, Lin H, Dingra NN, Outten CE, Keller G, Winge D, Ward DM, Kaplan J. J Biol Chem. 2008 Apr 18;283(16):10276-86.
Publications Prior to 2008