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All Publications

A complete listing of all publications by Caryn Outten on PubMed, maintained by the National Center for Biotechnology Information. Some articles are free to download via PubMed Central (PMC).

JBC 2023

Iron homeostasis proteins Grx4 and Fra2 control activity of the Schizosaccharomyces pombe iron repressor Fep1 by facilitating [2Fe-2S] cluster removal

Hati D, Brault A, Gupta M, Fletcher K, Jacques JF, Labbé S, Outten CE J Biol Chem. 2023 Dec;299(12):105419

Thiols book

The role of thiols in iron–sulfur cluster biogenesis

Bandyopadhyay T, Outten CE.  In "Redox Chemistry and Biology of Thiols" B Alvarez, MA Comini, G Salinas, N Trujillo, Eds.  Academic Press, 2022; p. 487-506.

BBA cover

Iron-sulfur cluster biogenesis, trafficking, and signaling: Roles for CGFS glutaredoxins and BolA proteins

Talib E, Outten CE Biochim Biophys Acta Mol Cell Res. 2021 Jan;1868(1):118847

COCB cover

Iron–sulfur cluster signaling: The common thread in fungal iron regulation

Gupta M, Outten CE Curr Opin Chem Biol. 2020 Apr;55:189-201

JBIC 2019

The conserved CDC motif in the yeast iron regulator Aft2 mediates iron-sulfur cluster exchange and protein-protein interactions with Grx3 and Bol2

 Li H, Outten CE. J Biol Inorg Chem. 2019 Sep;24(6):809-815


Characterization of glutaredoxin Fe–S cluster-binding interactions using circular dichroism spectroscopy

Albetel AN, Outten CE. Methods Enzymol. 2018;599:327-53.

Fe-S book

The role of Fe-S clusters in regulation of yeast iron homeostasis

Outten CE.  In "Iron-Sulfur Clusters in Chemistry and Biology, 2nd Edition; Vol. 2: Biochemistry, Biosynthesis, and Human Diseases" T. Rouault, Ed. Walter de Guyter GmbH, Berlin/Boston, 2017; p. 161-186.

JBC 2017

Checks and balances for the iron bank

Outten CE. J Biol Chem. 2017 Sep 22;292(38):15990-1.

Mol Cell 2017

Endoplasmic reticulum transport of glutathione by Sec61 is regulated by Ero1 and Bip

Ponsero AJ, Igbaria A, Darch MA, Miled S, Outten CE, Winther JR, Palais G, D'Autréaux B, Delaunay-Moisan A, Toledano MB. Mol Cell. 2017 Sep 21;67(6):962-73


Schizosaccharomyces pombe Grx4 regulates the transcriptional repressor Php4 via [2Fe–2S] cluster binding

Dlouhy AC, Beaudoin J, Labbé S, Outten CE. Metallomics. 2017 Aug 16;9(8):1096-1105

IbaG-Grx4 paper

The E. coli BolA protein IbaG forms a histidine-ligated [2Fe-2S] bridged complex with Grx4

Dlouhy AC, Li H, Albetel AN, Zhang B, Mapolelo DT, Randeniya S, Holland AA, Johnson MK, Outten CE. Biochemistry. 2016 Dec 13;55(49):6869-79.

Biochem 2016

The myeloablative drug busulfan converts cysteine to dehydroalanine and lanthionine in redoxins

Scian M, Guttman M, Bouldin SD, Outten CE, Atkins WM. Biochemistry. 2016 Aug 23;55(33):4720-30.  

JBC 2015 cover

Cytosolic Fe-S cluster protein maturation and iron regulation are independent of the mitochondrial Erv1/Mia40 import system

Ozer HK, Dlouhy AC, Thornton JD, Hu J, Liu Y, Barycki JJ, Balk J, Outten CE. J Biol Chem. 2015 Nov 13;290(46):27829-4.

Fe-S book

The role of Fe-S clusters in regulation of yeast iron homeostasis

Outten CE.  In "Iron-Sulfur Clusters in Chemistry and Biology," T. Rouault, Ed. Verlag Walter de Guyter GmbH, Berlin, Germany, 2014; p. 411-36.

PNAS 2014 cover

Molecular mechanism and structure of the Saccharomyces cerevisiae iron regulator Aft2

Poor CB, Wegner SV, Li H, Dlouhy AC, Schuermann JP, Sanishvili R, Hinshaw JR, Riggs-Gelasco PJ, Outten CE, He C. Proc Natl Acad Sci U S A. 2014 Mar 18;111(11):4043-8.

Curr Opin Microbiol

Iron sensing and regulation in Saccharomyces cerevisiae: Ironing out the mechanistic details

Outten CE, Albetel AN. Curr Opin Microbiol. 2013 Dec;16(6):662-8.

MILS 2013

The iron metallome in eukaryotic organisms

Dlouhy AC, Outten CE. Met Ions Life Sci. 2013;12:241-78.

Dalton Trans

Monothiol glutaredoxins and A-type proteins: partners in Fe-S cluster trafficking

Mapolelo DT, Zhang B, Randeniya S, Albetel AN, Li H, Couturier J, Outten CE, Rouhier N, Johnson MK. Dalton Trans. 2013 Mar 7;42(9):3107-15.

ARS 2013

Functions and cellular compartmentation of the thioredoxin and glutathione pathways in yeast

Toledano MB, Delaunay-Moisan A, Outten CE, Igbaria A. Antioxid Redox Signal. 2013 May 1;18(13):1699-711.

Biochem J 2012

Redox properties of the disulfide bond of human Cu,Zn superoxide dismutase and the effects of human glutaredoxin 1

Bouldin SD, Darch MA, Hart PJ, Outten CE. Biochem J. 2012 Aug 15;446(1):59-67.

Biochem 2012

Monothiol CGFS glutaredoxins and BolA-like proteins: [2Fe-2S] binding partners in iron homeostasis

Li H, Outten CE. Biochemistry. 2012 Jun 5;51(22):4377-89.  

FRBM 2012

Redox-sensitive YFP sensors monitor dynamic nuclear and cytosolic glutathione redox changes

Dardalhon M, Kumar C, Iraqui I, Vernis L, Kienda G, Banach-Latapy A, He T, Chanet R, Faye G, Outten CE, Huang ME. Free Radic Biol Med. 2012 Jun 1-15;52(11-12):2254-65.

Biochem 2012

Human glutaredoxin 3 forms [2Fe-2S]-bridged complexes with human BolA2

Li H, Mapolelo DT, Randeniya S, Johnson MK, Outten CE. Biochemistry. 2012 Feb 28;51(8):1687-96.

COCB 2011

Forging ahead: new mechanistic insights into iron biochemistry

Frey PA, Outten CE. Curr Opin Chem Biol. 2011 Apr;15(2):257-9.

JBC 2011

Histidine 103 in Fra2 is an iron-sulfur cluster ligand in the [2Fe-2S] Fra2-Grx3 complex and is required for in vivo iron signaling in yeast

Li H, Mapolelo DT, Dingra NN, Keller G, Riggs-Gelasco PJ, Winge DR, Johnson MK, Outten CE. J Biol Chem. 2011 Jan 7;286(1):867-76.

Biochem 2009

The yeast iron regulatory proteins Grx3/4 and Fra2 form heterodimeric complexes containing a [2Fe-2S] cluster with cysteinyl and histidyl ligation

Li H, Mapolelo DT, Dingra NN, Naik SG, Lees NS, Hoffman BM, Riggs-Gelasco PJ, Huynh BH, Johnson MK, Outten CE. Biochemistry. 2009 Oct 13;48(40):9569-81.

JBC 2009

Activation of Cu,Zn-superoxide dismutase in the absence of oxygen and the copper chaperone CCS

Leitch JM, Jensen LT, Bouldin SD, Outten CE, Hart PJ, Culotta VC. J Biol Chem. 2009 Aug 14;284(33):21863-71.

JBC 2008

The redox environment in the mitochondrial intermembrane space is maintained separately from the cytosol and matrix

Hu J, Dong L, Outten CE. J Biol Chem. 2008 Oct 24;283(43):29126-34.

Acta Crystal 2008

Structure of the thioredoxin-like domain of yeast glutaredoxin 3

Gibson LM, Dingra NN, Outten CE, Lebioda L. Acta Crystallogr D Biol Crystallogr. 2008 Sep;64(Pt 9):927-32.

JBC 2008

Identification of FRA1 and FRA2 as genes involved in regulating the yeast iron regulon in response to decreased mitochondrial iron-sulfur cluster synthesis

Kumánovics A, Chen OS, Li L, Bagley D, Adkins EM, Lin H, Dingra NN, Outten CE, Keller G, Winge D, Ward DM, Kaplan J. J Biol Chem. 2008 Apr 18;283(16):10276-86.


Publications Prior to 2008



Challenge the conventional. Create the exceptional. No Limits.