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School of Medicine Greenville

Faculty Profile

Faculty and Staff

Sergio Arce, M.D., Ph.D.

Title: Clinical Associate Professor
Biomedical Sciences
School of Medicine Greenville
Phone: 864-455-2258
Office: 701 Grove Road, Health Science Administration Building
Greenville SC 29605


Background: Dr. Arce brings extensive experience to the USC School of Medicine Greenville as an instructor of internal medicine, basic and clinical immunology and rheumatology, as a researcher and entrepreneur (he holds two patents), and as a widely published author and reviewer of medical and scientific publications. He studied at the Havana’s Higher Institute of Medical Sciences and National Institute of Nephrology in Cuba, and subsequently completed a doctoral dissertation on HLA compatibility and the receptor’s immune response, which studied 1,700 primary kidney transplants. Prior to joining the USC School of Medicine Greenville, Dr. Arce was an Assistant Professor in the Departments of Internal Medicine, Division of Pulmonary Critical Care and Sleep Medicine, Brody School of Medicine at East Carolina University and Adjunct Assistant Professor in the Department of Microbiology and Immunology, also at Brody. Concurrently, Dr. Arce was an Associate Member of the Witebsky Center for Microbial Pathogenesis and Immunology, Department of Microbiology and Immunology at State University of New York at Buffalo. Dr. Arce completed his postdoctoral studies at the prestigious German Rheumatism Research Center (DRFZ) and Charite University Medicine in Berlin, Germany.
Teaching Interest(s): At USC School of Medicine Greenville Dr. Arce teaches courses of internal medicine (clinical diagnosis and reasoning), basic and clinical immunology, pulmonary medicine and rheumatology.
Research Interest(s): Dr. Arce’s present research focuses on discovering novel roles for B and T lymphocytes in the pathogenesis of sarcoidosis, the biochemical mechanisms of steroid resistance in chronic persistent sarcoidosis and modeling the bone marrow plasma cell (myeloma) microenvironment and granulomatous inflammation in 3D culture systems. Dr. Arce is a prolific author and journal reviewer, with more than 80 peer-reviewed publications and abstracts presented at numerous national and international meetings. He has served as a reviewer for medical publications that include The Journal of Immunology, European Journal of Immunology, Clinical and Experimental Immunology, American Journal of Respiratory and Critical Care Medicine and Respiratory Medicine. He also holds two U.S. patents.
Honors & Awards: CHEST 2010 Young Investigator Award
Correlations between T-cell levels of MF-kB/p65 protein and variables of disease activity in sarcoidosis.
Professional Affiliations: American College of Physicians
American Thoracic Society
American Society for Microbiology
American Association of Immunologists
Buffalo Collegium of Immunology
New York Academy of Sciences

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