We have an active research focus in the neuroscience research and take full advantage of the University of South Carolina's status as a Tier 1 research university. Using cutting edge technology to aid in the understanding of neuropsychiatric and neurologic disorders, we provide insight into new treatment strategies and targets for these devastating diseases.
The faculty work across disciplines in numerous collaborative projects, and we have a strong neuroscience research portfolio with over $10 million dollars in extramurally funded research through the National Institutes of Health (NIH), National Science Foundation (NSF), the Veterans Administration and numerous foundations and endowment funds, including the Brain and Behavior Research Foundation and the American Heart Association.
Our dedicated faculty are leaders in research spanning a wide range of neuroscience-based areas including activities focus on the roles of specific molecules in cellular function and their importance to organismal physiology and behavior. Their work is published in high quality publications in high tier journals such as Nature Reviews Neuroscience, Biological Psychiatry, Molecular Psychiatry, Brain, Behavior & Immunity, PLoS One, Journal of Neuroscience, Diabetes, Neuroscience, Nanotechnology, Psychopharmacology and Experimental Neurology.
- Chronic stress, depression and cognition: Larry Reagan, James Fadel, Susan Wood, Marlene Wilson, Joe McQuail
- The fear circuit and PTSD: Alexander McDonald, Marlene Wilson, James Fadel, Larry Reagan, David Mott, Susan Wood
- Neurochemistry of stress: James Fadel, Claudia Grillo, Larry Reagan, Marlene Wilson
- Mitochondrial stress and protein modifications: Norma Frizzell, Gerardo Piroli
- Hippocampal dysregulation in depression: Larry Reagan, Claudia Grillo
- Individual differences in stress responses and cardiovascular disease: Susan Wood, Marlene Wilson
- Sleep deprivation and stress: Ana Pocivavsek
- Neuroanatomy of stress and emotion brain centers: Alexander McDonald, James Fadel, Larry Reagan, David Mott
- Sex differences in stress, anxiety and depression: Susan Wood, Marlene Wilson
- Phosphodiesterase signaling in depression, bipolar disorder and schizophrenia: Michy Kelly
- Protein modifications in diabetes: Norma Frizzell, Gerardo Piroli
- Neural basis for the co-morbidity of obesity and depression: Larry Reagan, Claudia Grillo
- Hippocampal dysfunction in metabolic syndrome: Larry Reagan
- Homeostatic changes in aging: James Fadel
- Serotonergic mechanisms in obesity: Claudia Grillo, Larry Reagan, James Fadel
- Hypothalamus and homeostasis: James Fadel, Larry Reagan, Claudia Grillo
- Brain mitochondrial disorders: Norma Frizzell, Gerardo Piroli
- Metabolic disorders and neural aging: Joe McQuail
- Novel therapeutic targets for neurodevelopmental diseases and aging: Michy Kelly, James Fadel, Larry Reagan.
- Basal forebrain cholinergic system in aging: James Fadel
- Cognitive impairments and sleep dysfunction in neuropsychiatric disorders: Ana Pocivavsek
- Cyclic nucleotide signaling in neurocognitive deficits: Michy Kelly
- Cognitive deficits in depression and diabetes: Larry Reagan, Claudia Grillo
- Neuropeptides, aging and cognition: James Fadel
- Protein modifications and mitochondrial stress in Parkinson’s disease: Norma Frizzell, Gerardo Piroli
- Amygdalar functional neuroanatomy and cognition: Alexander McDonald, David Mott, Marlene Wilson
- Molecular Mechanisms of age-related cognitive decline: Joe McQuail, Michy Kelly
- Glial regulation of mesolimbic dopamine pathways and motivated behaviors: Pavel Ortinski
- Neuroimmune changes induced by chronic psychosocial stress: Susan Wood, CS Wood
- Neuroimmune changes in Gulf War Illness: Larry Reagan, Claudia Grillo, CS Wood, Susan Wood, James Fadel
- Neuroinflammation and kynurenine pathway metabolism with sleep loss: Ana Pocivavsek
- Neuronal correlates of addictive behaviors: Pavel Ortinski, JR Turner
- Neuropeptide regulation of anxiety and alcohol consumption: Marlene Wilson, James Fadel
- Glutamate signaling in cocaine addiction: Pavel Ortinski
- Neural plasticity associated with nicotine addiction: Pavel Ortinski, JR Turner
- Novel screening tools for G-protein linked receptors including opioid receptors: Kenneth Walsh
- Individual differences in motivated behaviors and dopamine regulation: Pavel Ortinski, Marlene Wilson, JR Turner
Our Core Facilities
Our full-service viral vector core produces virus-based platforms for gene delivery. It is directed by Dr. Seungjin Shin.
Our machine shop fabricates and repairs custom lab equipment and renovates laboratory space. It is supervised by Mike Gore.
- Ken Walsh received funding from Trait Biosciences for his project on cannabinoids and receptor signaling
- Jim Fadel and Larry Reagan were chosen by the M1 and M2 students to present "Pearls of Wisdom"
- Michy Kelly received an NIH award totaling over $2.3 million for her research on "Role of cyclic nucleotide signaling in age-related decline of social memories"
- Britt Wilson received the Arthur C. Guyton educator of the year award from the American Physiological Society.
- David Mott received the Distinguished Research Service award from the USC Office of Research
- State service awards were given to Norma Frizzell (10 years), Kris Kaigler (20 years), Marlene Wilson (30 years) and Alex McDonald (40 years)
- Larry Reagan was elected into the Alpha Omega Alpha honor medical society.
- Shayne Barlow, PPN faculty and Attending Veterinarian and Director of the Department of Laboratory Animal Resources received the 2018 Education Foundation Outstanding Service Award
- Susan Wood receives NIH Award totaling over $2 million in total funding entitled: Estrogen mediated mechanisms of stress susceptibility
- Chris Wood is the newly appointed Assistant Director of Development for Corporate and Foundation Relations at USC. Congrats!
- Susan Wood has been approved as a new associate editor for JPET (Journal of Pharmacology & Experimental Therapeutics).
- Larry Reagan receives an award for over $400,000 from the Veterans Administration (VA) for purchasing a Quantum CX microCT Imaging System
PPN receives a USC ASPIRE AWARD:
- Gerardo Piroli is the recipient of an ASPIRE I (Innovation) award for studies of 'Intranasal insulin effects on behavioral, morphological and biochemical parameters in a model of Leigh syndrome'
- At the 2019 USC Neuroscience retreat, Josh Bratsch-Prince (David Mott mentor) was awarded best Oral presentation and Anna Marie Buchanan (Larry Reagan mentor) received the award for best graduate trainee poster.
- Katy Pilarzyk (Michy Kelly mentor) was awarded a 2019 National Science Foundation (NSF) Graduate Rearch Fellowship. This highly competitive 3-year fellowship provides an annual stipend of $34,000
plus an annual cost of education allowance of $12,000.
- Cole Calva (Jim Fadel mentor) successfully defended his doctoral dissertation.
- Nguyen Vu (David Mott mentor) successfully defended her master's thesis.
- Melinda Hersey (Reagan and Hashemi labs) received honorable mention for her presentation at the W. Morgan Newton graduate research symposium.
- Katy Pilarzyk (Michy Kelly mentor) was awarded a 2018-2019 SPARC Graduate Research grant from the Office of Research to support her research on the effects of social isolation.
- Reagan Farmer (Michy Kelly mentor) receives Magellan Scholar award and Magellan mini-grant for her research.
- David Smith (Michy Kelly mentor) receives Magellan mini-grant to fund his research
- Christopher “Grant” Morgan (Susan Wood mentor) receives Magellan Galen grant for summer research.
- Stephanie Martin (Norma Frizzell Mentor) successfully defended her Master’s thesis.
- Victoria Macht (Sandra Kelly and Larry Reagan mentors) successfully defended her PhD thesis entitled: Neurochemistry, Physiology and Behavior in a Model of Gulf War Illness
- Courtney Pinard, PhD (class of 2009) received the Distinguished Doctorate Alumni Award. Dr. Pinard completed her doctoral work on amygdalar anatomy with Alex McDonald.
- Julie Finnell (Susan Wood Mentor) receives Third Place Graduate and Post-baccalaureate Student Poster Award from the Division for Behavioral Pharmacology of the American Society of Pharmacology and Experimental Therapeutics (ASPET). This was awarded at the Experimental Biology meeting in San Diego, CA in April 2018.
- Welcome to Leandro Augusto de Oliveira, a visiting PhD student in Physiological Sciences at State University of São Paulo-UNESP (Araraquara, São Paulo, Brazil) working under supervision of Professor Carlos C. Crestani. Leandro is a fellow of the FAPESP research agency.
PPN award winners at DISCOVER USC 2019:
- Grant Morgan (Susan Wood mentor): 1st place in Pychology and Neuroscience, A division ('The role of microgila in the locus coeruleus in the cardiovascular sensitivity to stress').
- Reagan Farmer (Michy Kelly mentor). 1st place in Biology and Biomedical Sciences, C division ('PDE2A mRNA expression is altered in select brain regions of patients with major depressive disorder, schizophrenia, or bipolar disorder).
- Brittney Calatayud (Susan Wood mentor): 2nd place in Pyschology and Neuroscience, B division ('Mechanisms of anxiety-like behavior in females).
- Lee Augenblick (Susan Wood mentor) Honorable mention in Psychology and Neuroscience, C division ('Effect of clodronate on stess-induced neuroinflammation and anhedonia').
- Biomedical Pharmacology (PHPH 705) - 6 credit hour, fall semester. Basic principles of drug action for students in health professions. Course director Ken Walsh
- Physiology for the Health Sciences (PHPH 701) - 6 credit hours, spring semester. Basic principles of human physiology. Course director Ken Walsh
- Fundamental Neuroscience I (PHPH 750) - 4 credit hours, fall semester. Foundations of neuroanatomy and neurophysiology. Includes hands-on lab experience. Course director Alex McDonald
- Fundamental Neuroscience II (PHPH 751) - 4 credit hours, spring semester. Provides expanded instruction into neurological and neuropsychiatric disorders with a focus on current research. Course director David Mott
- Neuroscience (PHPH 740) - 4 credit hours, fall semester. Covers developmental and cellular neurobiology from a research perspective. Course director David Mott
- Neuroscience Seminar (PHPH 742) - 1 credit hour, both spring and fall semesters. Topics in professional development for scientists. Course directors vary. For information, contact David Mott
The Department of Pharmacology, Physiology and Neuroscience also supports a neuroscience concentration for Biomedical Science Ph.D. students.