Faculty and Staff
Lorne Hofseth, Ph.D.
|Title:||Professor / Drug Discovery and Biomedical Sciences
Interim Director Center for Colon Cancer Research
|College of Pharmacy|
Doctor of Philosophy
Simon Fraser University, Canada, Ph.D., 1996
Michigan State University (1996-2000)
National Cancer Institute (2000-2004)
Currently, our research interests revolve around chronic inflammation and cancer. Chronic inflammation is dangerous to human health. It drives many prevalent diseases in our society, including heart disease, diabetes, Alzheimer's, and cancer. Current treatment strategies that have a single target to dampen signs and symptoms of chronic inflammation are limited, and fraught with side-effects. Our lab is dedicated to identifying novel targets and therapeutic approaches to suppressing inflammation, with minimal toxicity. One way is through the use of common complementary and alternative medicines (CAMs) that have anti-inflammatory properties. Another way is to team up with biochemists who synthesize small molecule inhibitors of specific pro-inflammatory molecules with low toxicity. Dr. Hofseth also carries out clinical trials to examine the role of anti-oxidants in suppressing systemic inflammation, and improve overall health. Recent projects have involved the used of genetically modified plants to synthesize microRNAs for chemopreventive properties. We are also interested in colon cancer disparities and are tackling this issue in collaboration with other leaders at the University, including Drs. Hebert, Berger, and Roninson. Our bench-to-bedside approach and collaborative efforts will have far-reaching health implications on millions of people suffering from auto-immune and chronic inflammatory diseases. Dr. Hofseth has published over 86 times in peer-reviewed journals, and has founded two companies.
Selected Recent Publications (from 85 total):
Hofseth LJ. Getting rigorous with scientific rigor. Carcinogenesis. 39(1), 21-25, 2018. PMID: 28968787.
Witalison EE, Cui X, Hofseth AB, Subramanian V, Causey CP, Thompson PR, Hofseth LJ. Inhibiting protein arginine deiminases has antioxidant consequences. JPET;353(1):64-70, 2015. PMID: 25635139. PMCID: PMC4366755.
Cui X, Jin Y, Singh UP, Chumanevich AA, Harmon B, Cavicchia P, Hofseth AB, Kotakadi V, Poudyal D, Stroud B, Volate SR, Hurley TG, Hebert JR, Hofseth LJ. Suppression of DNA damage in human peripheral blood lymphocytes by a juice concentrate: a randomized, double-blind, placebo-controlled trial. Mol Nutr Food Res. 56:666-70, 2012. PMID: 22383296.
Harmon BE, Wirth MD, Boushey CJ, Wilkens LR, Draluck E, Shivappa N, Steck SE, Hofseth L, Haiman CA, Le Marchand L, Hébert JR. The Dietary Inflammatory Index Is Associated with Colorectal Cancer Risk in the Multiethnic Cohort. J Nutr. 147(3), 430-438, 2017. PMID: 28179489
Chumanevich AA, Chaparala A, Witalison EE, Tashkandi H, Hofseth AB, Lane C, Pena E, Liu P, Pittman DL, Nagarkatti P, Nagarkatti M, Hofseth LJ, Chumanevich AA. Looking for the best anti-colitis medicine: A comparative analysis of current and prospective compounds. Oncotarget. 8(1), 228-237, 2017. PMID: 27974688
Chumanevich AA, Witalison EE, Chaparala A, Chumanevich A, Nagarkatti P, Nagarkatti M, Hofseth LJ. Repurposing the anti-malarial drug, quinacrine: new anti-colitis properties. Oncotarget. 7(33), 52928-52939, 2016.
Block KI, et al. Designing a broad-spectrum integrative approach for cancer prevention and treatment. Semin Cancer Biol. 35, suppl. S276-304, 2015. PMID: 26590477