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College of Pharmacy

COBRE Publications


Priyanka Singh, Laura M Jenkins, Ben Horst, Victoria Alers, Shrikant Pradhan, Prabhjot Kaur, Tapasya Srivastava, Nadine Hempel, Balázs Győrffy, Eugenia V Broude, Nam Y Lee and Karthikeyan Mythreye.  Inhibin is a novel paracrine factor for tumor angiogenesis and metastasis.  Cancer Research.  March 13, 2018.

Alam A, Küng R, Kowal J, McLeod RA, Tremp N, Broude EV, Roninson IB, Stahlberg H, Locher KP. Structure of a zosuquidar and UIC2-bound human-mouse chimeric ABCB1. Proceedings of the National Academy of Sciences of the United States of America. 2018 Feb 27; 115(9):E1973-E1982.

Chukwurah E, Patel RC. Stress-induced TRBP phosphorylation enhances its interaction with PKR to regulate cellular survival. Scientific reports. 2018 January 18; 8(1):1020.


Jenkins LM, Horst B, Lancaster CL, Mythreye K. Dually modified transmembrane proteoglycans in development and disease. Cytokine & growth factor reviews. 2017 December 22.

Dasgupta S, Vliet SM, Kupsco A, Leet JK, Altomare D, Volz DC. Tris (1, 3-dichloro-2-propyl) phosphate disrupts dorsoventral patterning in zebrafish embryos. PeerJ. 2017 Dec 14; 5:e4156.

Manuel AM, Walla MD, Faccenda A, Martin SL, Tanis RM, Piroli GG, Adam J, Kantor B, Mutus B, Townsend DM, Frizzell N. Succination of Protein Disulfide Isomerase Mitochondrial Stress and Endoplasmic Reticulum Stress in the Adipocyte During Diabetes. Antioxidants & redox signaling. 2017 December 1; 27(16):1281-1296.

Choi RH, McConahay A, Jeong HW, McClellan JL, Hardee JP, Carson JA, Hirshman MF, Goodyear LJ, Koh HJ. Tribbles 3 regulates protein turnover in mouse skeletal muscle. Biochemical and biophysical research communications. 2017 November 25; 493(3):1236-1242.

Chapman CD, Schiöth HB, Grillo CA, Benedict C. Intranasal insulin in Alzheimer’s disease: Food for thought. Neuropharmacology. 2017 November 24.

Chen M, Liang J, Ji H, Yang Z, Altilia S, Hu B, Schronce A, McDermott MSJ, Schools GP, Lim CU, Oliver D, Shtutman MS, Lu T, Stark GR, Porter DC, Broude EV, Roninson IB. CDK8/19 Mediator kinases potentiate induction of transcription by NFκB. Proceedings of the National Academy of Sciences of the United States of America. 2017 September 19; 114(38):10208-10213.

Varadaraj A, Jenkins LM, Singh P, Chanda A, Snider J, Lee NY, Amsalem-Zafran AR, Ehrlich M, Henis YI, Mythreye K. TGF-β triggers rapid fibrillogenesis via a novel TβRIIdependent fibronectin-trafficking mechanism. Molecular biology of the cell. 2017 May 1; 28(9):1195-1207.

Chukwurah E, Handy I, Patel RC. ADAR1 and PACT contribute to efficient translation of transcripts containing HIV-1 trans-activating response (TAR) element. The Biochemical journal. 2017 March 23; 474(7):1241-1257.

Oliver D, Ji H, Liu P, Gasparian A, Gardiner E, Lee S, Zenteno A, Perinskaya LO, Chen M, Buckhaults P, Broude E, Wyatt MD, Valafar H, Peña E, Shtutman M. Identification of novel cancer therapeutic targets using a designed and pooled shRNA library screen. Scientific reports. 2017 February 22; 7:43023.

Pan CC, Shah N, Kumar S, Wheeler SE, Cinti J, Hoyt DG, Beattie CE, An M, Mythreye K, Rakotondraibe LH, Lee NY. Angiostatic actions of capsicodendrin through selective inhibition of VEGFR2-mediated AKT signaling and disregulated autophagy. Oncotarget. 2017 February 21; 8(8):12675-12685.

McDermott MS, Chumanevich AA, Lim CU, Liang J, Chen M, Altilia S, Oliver D, Rae JM, Shtutman M, Kiaris H, Győrffy B, Roninson IB, Broude EV. Inhibition of CDK8 mediator kinase suppresses estrogen dependent transcription and the growth of estrogen receptor positive breast cancer. Oncotarget. 2017 February 21; 8(8):12558-12575.

Vassoler FM, Oliver DJ, Wyse C, Blau A, Shtutman M, Turner JR, Byrnes EM. Transgenerational attenuation of opioid self-administration as a consequence of adolescent morphine exposure. Neuropharmacology. 2017 February; 113(Pt A):271-280.

Shtutman M, Chang BD, Schools GP, Broude EV. Cellular Model of p21-Induced Senescence. Methods in molecular biology (Clifton, N.J.). 2017; 1534:31-39.

Zhang Y, Davis C, Shah S , Hughes D, Ryan JC, Altomare D, Peña MM. IL-33 promotes growth and liver metastasis of colorectal cancer in mice by remodeling the tumor microenvironment and inducing angiogenesis. Mol Carcinog. 2017 Jan; 56(1):272-287.

Lunev S, Semmelink MF, Xian JL, Ma KY, Leenders AJ, Dömling AS, Shtutman M, Groves MR. Crystal structure of truncated human coatomer protein complex subunit ζ1 (Copζ1). Acta crystallographica. Section F, Structural biology communications. 2017 January 1; 73(Pt 1):1-8.


Jenkins LM, Singh P, Varadaraj A, Lee NY, Shah S, Flores HV, O'Connell K, Mythreye K. Altering the Proteoglycan State of Transforming Growth Factor β Type III Receptor (TβRIII)/Betaglycan Modulates Canonical Wnt/β-Catenin Signaling. The Journal of biological chemistry. 2016 December 2; 291(49):25716-25728.

Hegde S, Ji H, Oliver D, Patel NS, Poupore N, Shtutman M, Kelly MP. PDE11A regulates social behaviors and is a key mechanism by which social experience sculpts the brain. Neuroscience. 2016 October 29; 335:151-69.

Zhou L, Andersen H, Arreola AC, Turner JR, Ortinski PI. Behavioral History of Withdrawal Influences Regulation of Cocaine Seeking by Glutamate Re-Uptake. PloS one. 2016 September 29; 11(9):e0163784.

Kumar S, Pan CC, Shah N, Wheeler SE, Hoyt KR, Hempel N, Mythreye K, Lee NY. Activation of Mitofusin2 by Smad2-RIN1 Complex during Mitochondrial Fusion. Molecular cell. 2016 May 19; 62(4):520-31.

Patel Y, Shah N, Lee JS, Markoutsa E, Jie C, Liu S, Botbyl R, Reisman D, Xu P, Chen H. A novel double-negative feedback loop between miR-489 and the HER2-SHP2- MAPK signaling axis regulates breast cancer cell proliferation and tumor growth. Oncotarget. 2016 April 5; 7(14):18295-308.

Cheng B, He H, Huang T, Berr SS, He J, Fan D, Zhang J, Xu P. Gold Nanosphere Gated Mesoporous Silica Nanoparticle Responsive to Near-Infrared Light and Redox Potential as a Theranostic Platform for Cancer Therapy. Journal of biomedical nanotechnology. 2016 March; 12(3):435-49.

Jeong HW, Choi RH, McClellan JL, Piroli GG, Frizzell N, Tseng YH, Goodyear LJ, Koh HJ. Tribbles 3 inhibits brown adipocyte differentiation and function by suppressing insulin signaling. Biochem Biophys Res Commun. 2016 Feb 19; 470(4):783-91.

White SL, Ortinski PI, Friedman SH, Zhang L, Neve RL, Kalb RG, Schmidt HD, Pierce RC. A Critical Role for the GluA1 Accessory Protein, SAP97, in Cocaine Seeking. Neuropsychopharmacology: official publication of the American College of Neuropsychopharmacology. 2016 February; 41(3):736-50.

Piroli GG, Manuel AM, Clapper AC, Walla MD, Baatz JE, Palmiter RD, Quintana A, Frizzell N. Succination is Increased on Select Proteins in the Brainstem of the NADH dehydrogenase (ubiquinone) Fe-S protein 4 (Ndufs4) Knockout Mouse, a Model of Leigh Syndrome. Mol Cell Proteomics. 2016 Feb; 15(2):445-61.


Rai R, Zhang F, Colavita K, Leu NA, Kurosaka S, Kumar A, Birnbaum MD, Győrffy B, Dong DW, Shtutman M, Kashina A. Arginyltransferase suppresses cell tumorigenic potential and inversely correlates with metastases in human cancers. Oncogene. 2015 Dec 21.

He H, Altomare D, Ozer U, Xu H, Creek K, Chen H, Xu P. Cancer cell-selective killing polymer/copper combination. Biomater Sci. 2015 Dec 15; 4(1):115-20.

Varadaraj A, Patel P, Serrao A, Bandyopadhay T, Lee NY, Jazaeri AA, Huang Z, Murphy SK, Mythreye K. Epigenetic Regulation of GDF2 Suppresses Anoikis in Ovarian and Breast Epithelia. Neoplasia. 2015 Nov; 17(11):826-38.

Provence A, Malysz J, Petkov GV. The Novel KV72/KV73 Channel Opener ICA-069673 Reveals Subtype-Specific Functional Roles in Guinea Pig Detrusor Smooth Muscle Excitability and Contractility. J Pharmacol Exp Ther. 2015 Sep; 354(3):290-301.

Gasparian A, Daneshian L, Ji H, Jabbari E, Shtutman M. Purification of high-quality RNA from synthetic polyethylene glycol-based hydrogels. Anal Biochem. 2015 Sep 1; 484:1-3.

Gomez AM, Altomare D, Sun WL, Midde NM, Ji H, Shtutman M, Turner JR, Creek KE, Zhu J. Prefrontal microRNA-221 Mediates Environmental Enrichment-Induced Increase of Locomotor Sensitivity to Nicotine. Int J Neuropsychopharmacol. 2015 Aug 1; 19(1).

Pan CC, Kumar S, Shah N, Bloodworth JC, Hawinkels LJ, Mythreye K, Hoyt DG, Lee NY. Endoglin Regulation of Smad2 Function Mediates Beclin1 Expression and Endothelial Autophagy. J Biol Chem. 2015 Jun 12; 290(24):14884-92.

Levina E, Ji H, Chen M, Baig M, Oliver D, Ohouo P, Lim CU, Schools G, Carmack S, Ding Y, Broude EV, Roninson IB, Buttyan R, Shtutman M. Identification of novel genes that regulate androgen receptor signaling and growth of androgen-deprived prostate cancer cells. Oncotarget. 2015 May 30; 6(15):13088-104.

Bei C, Bindu T, Remant KC, Peisheng X. Dual secured nano-melittin for the safe and effective eradication of cancer cells. Journal of materials chemistry. B, Materials for biology and medicine. 2015 January 7; 3(1):25-29.

Tanis RM, Piroli GG, Day SD, Frizzell N. The effect of glucose concentration and sodium phenylbutyrate treatment on mitochondrial bioenergetics and ER stress in 3T3-L1 adipocytes. Biochimica et biophysica acta. 2015 January; 1853(1):213-21.

Broude EV, Győrffy B, Chumanevich AA, Chen M, McDermott MS, Shtutman M, Catroppo JF, Roninson IB. Expression of CDK8 and CDK8-interacting Genes as Potential Biomarkers in Breast Cancer. Curr Cancer Drug Targets. 2015; 15(8):739-49.


He H, Cattran AW, Nguyen T, Nieminen AL, Xu P. Triple-responsive expansile nanogel for tumor and mitochondria targeted photosensitizer delivery. Biomaterials. 2014 Nov; 35(35):9546-53.

Piroli GG, Manuel AM, Walla MD, Jepson MJ, Brock JW, Rajesh MP, Tanis RM, Cotham WE, Frizzell N. Identification of protein succination as a novel modification of tubulin. Biochem J. 2014 Sep 1; 462(2):231-45.