Skip to Content

College of Pharmacy

Dr. Igor Roninson

COBRE Center for Targeted Therapeutics

Publications

Through pilot projects and collaborative studies, our research at the Center for Targeted Therapeutics encompasses targeted therapeutics for multiple diseases. Explore our index of publications.

Title Authors Journal Year Keywords
(hidden column)
CDK7 Inhibition is Effective in all the Subtypes of Breast Cancer: Determinants of Response and Synergy with EGFR Inhibition  McDermott MSJ, Sharko AC, Munie J, Kassler S, Melendez T, Lim CU, Broude EV Cells 2020  tag 1, tag2
A Highly Potent TACC3 Inhibitor as a Novel Anti-cancer Drug Candidate Akbulut O, Lengerli D, Saatci O, Duman E, Seker UOS, Isik A, Akyol A, Caliskan B, Banoglu E, Sahin O Molecular Cancer Therapeutics 2020   
Targeting lysyl oxidase (LOX) overcomes chemotherapy resistance in triple negative breast cancer Saatci O, Kaymak A, Raza U, Ersan PG, Akbulut O, Banister CE, Sikirzhytski V, Tokat UM, Aykut G, Ansari SA, Dogan HT, Dogan M, Jandaghi P, Isik A, Gundogdu F, Kosemehmetoglu K, Disdar O, Aksoy S, Akyol A, Uner A, Buckhaults PJ, Riazalhosseini Y, Sahin O Nature Communications 2020   
TRB3 regulates skeletal muscle mass in food deprivation-induced atrophy Choi RH, McConahay A, Silvestre JG, Moriscot AS, Carson JA, Koh HJ The FASEB Journal 2019  
Role of transcription-regulating kinase CDK8 in colon cancer metastasis Liang J, Chen M, Broude EV, Roninson IB Oncotarget 2019  
Repurposing suramin for the treatment of breast cancer lung metastasis with glycol chitosan-based nanoparticles Cheng B, Gao F, Maissy E, Xu P Acta Biomaterialia 2019  
Structural insight into substrate and inhibitor discrimination by human P-glycoprotein Alam A, Kowal J, Broude E, Roninson I, Locher KP Science 2019   
Identification of Novel Protein Targets of Dimethyl Fumarate Modification in Neurons and Astrocytes Reveals Actions Independent of Nrf2 Stabilization  Piroli GG, Manuel AM, Patel T, Walla MD, Shi L, Lanci SA, Wang J, Galloway A, Ortinski PI, Smith DS, Frizzell N Molecular & Cellular Proteomics 2019   
Human CST suppresses origin licensing and promotes AND-1/Ctf4 chromatin association Wang Y, Brady KS, Caiello BP, Ackerson SM, Stewart JA Life Science Alliance 2019   
Nicotinamide Augments the Anti-Inflammatory Properties of Resveratrol through PARP1 Activation Yanez M, Jhanji M, Murphy K, Gower RM, Sajish M, Jabbarzadeh E Scientific Reports 2019   
Acute and short-term administrations of delta-9-tetrahydrocannabinol modulate major gut metabolomic regulatory pathways in C57BL/6 mice Oza M, Becker W, Gummadidala PM, Dias T, Omebeyinje MH, Chen L, Mitra C, Jesmin R, Chakraborty P, Sajish M, Hofseth LJ, Banerjee K, Wang Q, Moeller PDR, Nagarkatti M, Nagarkatti P, Chanda A Scientific Reports 2019   
Identifying Cancers Impacted by CDK8/19 Roninson IB, Gyorffy B, Mack ZT, Shtil AA, Shtutman MS, Chen M, Broude EV Cells 2019   
HPV16-transformed human keratinocytes depend on SIX1 expression for proliferation and HPV E6/E7 gene expression Hosseinipour M, Wan F, Altomare D, Creek KE, Pirisi L Virology 2019  
Development of microparticles for controlled release of resveratrol to adipose tissue and the impact of drug loading on particle morphology and drug release Isely C, Hendley MA, Murphy KP, Kader S, Annamalai P, Jabbari E, Gower RM International Journal of Pharmaceutics 2019  
Systems-level Analysis Reveals Multiple Modulators of Epithelial-mesenchymal Transition and Identifies DNAJB4 and CD81 as Novel Metastasis Inducers in Breast Cancer Uretmen Kagiali ZC, Sanal E, Karayel O, Polat AN, Saatci O, Ersan PG, Trappe K, Renard BY, Onder TT, Tuncbag N, Sahin O, Ozlu N Molecular & Cellular Proteomics 2019  
The host response to poly(lactide-co-glycolide) scaffolds protects mice from diet induced obesity and glucose intolerance Hendley MA, Murphy KP, Isely C, Struckman HL, Annamalai P, Gower RM Biomaterials 2019  
Characterizing CDK8/19 Inhibitors through a NFκB-Dependent Cell-Based Assay Li J, Ji H, Porter DC, Broude EV, Roninson IB, Chen M Cells 2019  
Systemic Toxicity Reported for CDK8/19 Inhibitors CCT251921 and MSC2530818 Is Not Due to Target Inhibition Chen M, Li J, Liang J, Thompson ZS, Kathrein K, Broude EV, Roninson IB Cells 2019  
Thymidylate synthase maintains the de-differentiated state of triple negative breast cancers Siddiqui A, Gollavilli PN, Schwab A, Vazakidou ME, Ersan PG, Ramakrishnan M, Pluim D, Coggins S, Saatci O, Annaratone L, Hm Schellens J, Kim B, Asangani IA, Rasheed SAK, Marchio C, Sahin O, Ceppi P Cell Death & Differentiation 2019  
Inhibition of the Dead Box RNA Helicase 3 Prevents HIV-1 Tat and Cocaine-Induced Neurotoxicity by Targeting Microglia Activation Aksenova M, Sybrandt J, Cui B, Sikirzhytski V, Ji H, Odhiambo D, Lucius MD, Turner JR, Broude E, Peña E, Lizarraga S, Zhu J, Safro I, Wyatt MD, Shtutman M Journal of Neuroimmune Pharmacology 2019  
The Meisenheimer Complex as a paradigm in drug discovery: reversible covalent inhibition through C67 of the ATP binding site of PLK1 Pearson RJ, Blake DG, Mezna M, Fischer PM, Westwood NJ, McInnes C Cell Chemical Biology 2018  
Insulin Resistance as a Therapeutic Target in the Treatment of Alzheimer's Disease: A State-of-the-Art Review Benedict C, Grillo CA Frontiers in Neuroscience 2018  
hnRNPs binding to the axonal localization motifs of Nrn1 and HMGB1 mRNAs define growth-associated RNA regulons Lee SJ, Oses-Prieto JA, Kawaguchi R, Sahoo PK, Kar AN, Rozenbaum M, Oliver D, Chand S, Ji H, Shtutman M, Miller-Randolph S, Taylor RJ, Fainzilber M, Coppola G, Burlingame AL, Twiss JL Molecular & Cellular Proteomics 2018  
CDK8 selectively promotes the growth of colon cancer metastases in the liver by regulating gene expression of TIMP3 and matrix metalloproteinases Liang J, Chen M, Hughes D, Chumanevich AA, Altilia S, Kaza V, Lim CU, Kiaris H, Mythreye K, Pena MM, Broude EV, Roninson IB Cancer Research 2018  
Impact of nutrition on inflammation, taupathy, and behavioral outcomes from chronic traumatic encephalopathy Yu J, Zhu H, Taheri S, Mondy W, Perry S, Kindy MS Journal of Neuroinflammation 2018  
Deoxycholate fractionation of fibronectin (FN) and biotinylation assay to measure recycled FN fibrils in epithelial cells Varadaraj A, Magdaleno C, Mythreye K Bio-protocol 2018  
Mediator kinase CDK8/CDK19 drives YAP1-dependent BMP4-induced EMT in cancer Serrao A, Jenkins LM, Chumanevich AA, Horst B, Liang J, Gatza ML, Lee NY, Roninson IB, Broude EV, Mythreye K Oncogene 2018  
Inhibin is a novel paracrine factor for tumor angiogenesis and metastasis Singh P, Jenkins LM, Horst B, Alers V, Pradhan S, Kaur P, Srivastava T, Hempel N, Győrffy B, Broude EV, Lee NY, Mythreye K Cancer Research 2018  
Dually modified transmembrane proteoglycans in development and disease Jenkins LM, Horst B, Lancaster CL, Mythreye K Cytokine & Growth Factor Reviews 2018  
Structure of a zosuquidar and UIC2-bound human-mouse chimeric ABCB1 Alam A, Kung R, Kowal J, Mcleod RA, Tremp N, Broude EV, Roninson IB, Stahlberg H, Locher KP Proceedings of the National Academy of Sciences of the United States of America 2018  
Stress-Induced TRBP phosphorylation enhances its interaction with PKR to regulate cellular survival

2018 Pilot Project Publication

Chukwurah E, Patel RC Scientific Reports 2018  
Dually modified transmembrane proteoglycans in development and disease Jenkins LM, Horst B, Lancaster CL, Mythreye K Cytokine & Growth Factor Reviews 2017  
Tris (1, 3-dichloro-2-propyl) phosphate disrupts dorsoventral patterning in zebrafish embryos Dasgupta S, Vliet SM, Kupsco A, Leet JK, Altomare D, Volz DC PeerJ 2017  
Succination of Protein Disulfide Isomerase Mitochondrial Stress and Endoplasmic Reticulum Stress in the Adipocyte During Diabetes Manuel AM, Walla MD, Faccenda A, Martin SL, Tanis RM, Piroli GG, Adam J, Kantor B, Mutus B, Townsend DM, Frizzell N Antioxidants & Redox Signaling 2017  
CDK8/19 Mediator kinases potentiate induction of transcription by NFκB Chen M, Liang J, Ji H, Yang Z, Altilia S, Hu B, Schronce A, McDermott MSJ, Schools GP, Lim CU, Oliver D, Shtutman MS, Lu T, Stark GR, Porter DC, Broude EV, Roninson IB Proceedings of the National Academy of Sciences of the United States of America

 

2017  
TGF-β triggers rapid fibrillogenesis via a novel TβRIIdependent fibronectin-trafficking mechanism Varadaraj A, Jenkins LM, Singh P, Chanda A, Snider J, Lee NY, Amsalem-Zafran AR, Ehrlich M, Henis YI, Mythreye K Molecular Biology of the Cell 2017  
Identification of novel cancer therapeutic targets using a designed and pooled shRNA library screen Oliver D, Ji H, Liu P, Gasparian A, Gardiner E, Lee S, Zenteno A, Perinskaya LO, Chen M, Buckhaults P, Broude E, Wyatt MD, Valafar H, Pena E, Shtutman M Scientific Reports 2017  
Angiostatic actions of capsicodendrin through selective inhibition of VEGFR2-mediated AKT signaling and disregulated autophagy Pan CC, Shah N, Kumar S, Wheeler SE, Cinti J, Hoyt DG, Beattie CE, An M, Mythreye K, Rakotondraibe LH, Lee NY Oncotarget 2017  
Inhibition of CDK8 mediator kinase suppresses estrogen dependent transcription and the growth of estrogen receptor positive breast cancer McDermott MS, Chumanevich AA, Lim CU, Liang J, Chen M, Altilia S, Oliver D, Rae JM, Shtutman M, Kiaris H, Gyorffy B, Roninson IB, Broude EV Oncotarget 2017  
Transgenerational attenuation of opioid self-administration as a consequence of adolescent morphine exposure Vassoler FM, Oliver DJ, Wyse C, Blau A, Shtutman M, Turner JR, Byrnes EM Neuropharmacology 2017  
Cellular Model of p21-Induced Senescence Shtutman M, Chang BD, Schools GP, Broude EV Methods in Molecular Biology 2017  
IL-33 promotes growth and liver metastasis of colorectal cancer in mice by remodeling the tumor microenvironment and inducing angiogenesis Zhang Y, Davis C, Shah S , Hughes D, Ryan JC, Altomare D, Pena MM Molecular Carcinogenesis 2017  
Crystal structure of truncated human coatomer protein complex subunit ζ1 (Copζ1) Lunev S, Semmelink MF, Xian JL, Ma KY, Leenders AJ, Domling AS, Shtutman M, Groves MR Acta Crystallographica Section F 2017  
ADAR1 and PACT contribute to efficient translation of transcripts containing HIV-1 trans-activating response (TAR) element

2017 Pilot Project Publication

Chukwurah E, Handy I, Patel RC Biochemical Journal 2017  
Intranasal insulin in Alzheimer's Disease: Food for thought

2017 Pilot Project Publication

Chapman CD, Schioth HB, Grillo C, Benedict C Neuropharmacology 2017  
Tribbles 3 regulates protein turnover in mouse skeletal muscle

2017 Pilot Project Publication

Choi RH, McConahay A, Jeong H, McClellan JL, Hardee JP, Carson JA, Hirshman MF, Goodyear LJ, Koh HJ Biochemical and Biophysical Research Communications 2017  
Altering the Proteoglycan State of Transforming Growth Factor β Type III Receptor (TβRIII)/Betaglycan Modulates Canonical Wnt/β-Catenin Signaling Jenkins LM, Singh P, Varadaraj A, Lee NY, Shah S, Flores HV, O'Connell K, Mythreye K Journal of Biological Chemistry 2016  
PDE11A regulates social behaviors and is a key mechanism by which social experience sculpts the brain Hegde S, Ji H, Oliver D, Patel NS, Poupore N, Shtutman M, Kelly MP Neuroscience 2016  
Activation of Mitofusin2 by Smad2-RIN1 Complex during Mitochondrial Fusion Kumar S, Pan CC, Shah N, Wheeler SE, Hoyt KR, Hempel N, Mythreye K, Lee NY Molecular Cell 2016  
A novel double-negative feedback loop between miR-489 and the HER2-SHP2- MAPK signaling axis regulates breast cancer cell proliferation and tumor growth Patel Y, Shah N, Lee JS, Markoutsa E, Jie C, Liu S, Botbyl R, Reisman D, Xu P, Chen H Oncotarget 2016  
Gold Nanosphere Gated Mesoporous Silica Nanoparticle Responsive to Near-Infrared Light and Redox Potential as a Theranostic Platform for Cancer Therapy Cheng B, He H, Huang T, Berr SS, He J, Fan D, Zhang J, Xu P Journal of Biomedical Nanotechnology 2016  
Tribbles 3 inhibits brown adipocyte differentiation and function by suppressing insulin signaling Jeong HW, Choi RH, McClellan JL, Piroli GG, Frizzell N, Tseng YH, Goodyear LJ, Koh HJ Biochemical and Biophysical Research Communications 2016  
Succination is Increased on Select Proteins in the Brainstem of the NADH dehydrogenase (ubiquinone) Fe-S protein 4 (Ndufs4) Knockout Mouse, a Model of Leigh Syndrome Piroli GG, Manuel AM, Clapper AC, Walla MD, Baatz JE, Palmiter RD, Quintana A, Frizzell N Molecular & Cellular Proteomics 2016  
A Critical Role for the GluA1 Accessory Protein, SAP97, in Cocaine Seeking

2016 Pilot Project Publication

White S, Ortinski P, Friedman SH, Zhang L, Neve R, Kalb RG, Schmidt HD, Pierce RC Neuropsychopharmacology 2016  
Behavioral History of Withdrawal Influences Regulation of Cocaine Seeking by Glutamate Reuptake

2016 Pilot Project Publication

Zhou L, Anderson H, Arreola AC, Turner J, Ortinski PI PLOS One 2016  
Arginyltransferase suppresses cell tumorigenic potential and inversely correlates with metastases in human cancers Rai R, Zhang F, Colavita K, Leu NA, Kurosaka S, Kumar A, Birnbaum MD, Gyorffy B, Dong DW, Shtutman M, Kashina A Oncogene 2015  
Cancer cell-selective killing polymer/copper combination He H, Altomare D, Ozer U, Xu H, Creek K, Chen H, Xu P Biomaterials Science 2015  
Epigenetic Regulation of GDF2 Suppresses Anoikis in Ovarian and Breast Epithelia Varadaraj A, Patel P, Serrao A, Bandyopadhay T, Lee NY, Jazaeri AA, Huang Z, Murphy SK, Mythreye K Neoplasia 2015  
Purification of high-quality RNA from synthetic polyethylene glycol-based hydrogels Gasparian A, Daneshian L, Ji H, Jabbari E, Shtutman M Analytical Biochemistry 2015  
Prefrontal microRNA-221 Mediates Environmental Enrichment-Induced Increase of Locomotor Sensitivity to Nicotine Gomez AM, Altomare D, Sun WL, Midde NM, Ji H, Shtutman M, Turner JR, Creek KE, Zhu J. The International Journal of Neuropsychopharmacology 2015  
Endoglin Regulation of Smad2 Function Mediates Beclin1 Expression and Endothelial Autophagy Pan CC, Kumar S, Shah N, Bloodworth JC, Hawinkels LJ, Mythreye K, Hoyt DG, Lee NY Journal of Biological Chemistry 2015  
Identification of novel genes that regulate androgen receptor signaling and growth of androgen-deprived prostate cancer cells Levina E, Ji H, Chen M, Baig M, Oliver D, Ohouo P, Lim CU, Schools G, Carmack S, Ding Y, Broude EV, Roninson IB, Buttyan R, Shtutman M Oncotarget 2015  
Dual secured nano-melittin for the safe and effective eradication of cancer cells. Journal of materials chemistry Bei C, Bindu T, Remant KC, Peisheng X Journal of Materials Chemistry B 2015  
The effect of glucose concentration and sodium phenylbutyrate treatment on mitochondrial bioenergetics and ER stress in 3T3-L1 adipocytes Tanis RM, Piroli GG, Day SD, Frizzell N Biochimica et Biophysica Acta 2015  
Expression of CDK8 and CDK8-interacting Genes as Potential Biomarkers in Breast Cancer Broude EV, Gyorffy B, Chumanevich AA, Chen M, McDermott MS, Shtutman M, Catroppo JF, Roninson IB Current Cancer Drug Targets 2015  
The Novel KV7.2/KV7.3 Channel Opener ICA-069673 Reveals Subtype-Specific Functional Roles in Guinea Pig Detrusor Smooth Muscle Excitability and Contractility

2015 Pilot Project Publication

Provence A, Malysz J, Petkov, GV Journal of Pharmacology and Experimental Therapeutics 2015  
Triple-responsive expansile nanogel for tumor and mitochondria targeted photosensitizer delivery He H, Cattran AW, Nguyen T, Nieminen AL, Xu P Biomaterials 2014  
Identification of protein succination as a novel modification of tubulin Piroli GG, Manuel AM, Walla MD, Jepson MJ, Brock JW, Rajesh MP, Tanis RM, Cotham WE, Frizzell N Biochemical Journal 2014  

 

 


Challenge the conventional. Create the exceptional. No Limits.

©