The DDSC will work with researchers to evaluate the feasibility of drug discovery and design projects with the following applications and services:

Drug Target and Mode of Action types

• Small molecule enzyme inhibitors: kinases, phosphatases etc.
• Protein – protein and protein – nucleic acid interactions
• Antibody-drug conjugates

Our Services

• Evaluation of potential targets for “drugability”
• Ligand and structure based virtual screening to identify initial hits for drug discovery
• In silico prediction of pharmacokinetic and ADME properties.
• Synthesis of small molecule, peptide and peptidomimetic compounds
• Structure based design to optimize ligand affinity, cellular activity and drug-likeness.
• Library design and synthesis to evaluate structure-activity relationships.
• Isolation and purification services.
• Design and synthesis of antibody-drug conjugates.

Facilities and Equipment

• 1200 Sq. Ft. Fully equipped Synthetic Chemistry laboratory
• Waters Fully Automated Mass Directed Preparative HPLC system.
• Biotage Automated Flash Chromatography system.
• Protein Technologies 6 channel fully automated parallel peptide and solid phase organic synthesizer.
• Chembridge “DIVERSet” compound collection for compound screening
• State of the Art Molecular Modeling/Computational Chemistry Software and Hardware for Ligand and Structure Based Molecular Design.
• Access to UofSC high performance computing facilities for docking of virtual molecular libraries of zinc database (35 million purchasable compounds).