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College of Pharmacy

Faculty and Staff

Phillip Buckhaults, Ph.D.

Title: Professor
Department: Drug Discovery & Biomedical Sciences (DDBS)
College of Pharmacy
Phone: 803-777-3621
Office: Jones Physical Sciences Center
745 Main Street - PSC 620
Columbia, SC 29208
Phillip Buckhaults portrait


Ph.D.  Biochemistry and Molecular Biology, University of Georgia, 1996
M.S.  Biochemistry and Molecular Biology, University of California, San Diego, 1991
B.S.  Chemistry, University of South Florida, 1988


Phillip Buckhaults, Ph.D., is an experienced molecular biologist and cancer geneticists who has extensive experience with next-gen sequencing applications for global gene expression analysis and gene mutation detection.

Buckhaults characterized the expression landscapes of colon tumors to identify signatures of recurrence and the mutation landscapes of breast and colon tumors to identify novel cancer genes, and he has profiled cancer gene mutation signatures in melanomas to determine novel therapeutic modalities based on targeting PI3K and BRAF pathways.

Buckhaults uses somatic cell knockout technology to characterized variant alleles in human cells and has discovered novel functions of a polymorphism in the TP53 gene.

Research Interests

The Buckhaults Lab Research is focused on: 

  • Determining biochemical mechanisms by which germline variants contribute to cancer health disparities that exist between people of different ethnic ancestries
  • Using genome sequencing and functional genomics to develop novel personalized medicine approaches to treat colon cancer


Transcriptomes and shRNA Suppressors in a TP53 Allele–Specific Model of Early-Onset Colon Cancer in African Americans

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